The frequency of CD38
Animals
Macrophages, Alveolar
/ immunology
Mycobacterium tuberculosis
/ immunology
Lung
/ immunology
Mice
ADP-ribosyl Cyclase 1
/ metabolism
Mice, Inbred C57BL
Disease Models, Animal
Female
Tuberculosis, Pulmonary
/ immunology
Membrane Glycoproteins
/ metabolism
BCG Vaccine
/ immunology
Single-Cell Analysis
Tuberculosis
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
06
02
2024
accepted:
24
09
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
2
10
2024
Statut:
epublish
Résumé
Tuberculosis, caused by Mycobacterium tuberculosis, remains an enduring global health challenge due to the limited efficacy of existing treatments. Although much research has focused on immune failure, the role of host macrophage biology in controlling the disease remains underappreciated. Here we show, through multi-modal single-cell RNA sequencing in a murine model, that different alveolar macrophage subsets play distinct roles in either advancing or controlling the disease. Initially, alveolar macrophages that are negative for the CD38 marker are the main infected population. As the infection progresses, CD38
Identifiants
pubmed: 39358361
doi: 10.1038/s41467-024-52846-w
pii: 10.1038/s41467-024-52846-w
doi:
Substances chimiques
ADP-ribosyl Cyclase 1
EC 3.2.2.6
Cd38 protein, mouse
EC 3.2.2.5
Membrane Glycoproteins
0
BCG Vaccine
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8522Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : AI155319
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : AI162598
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : AI134183
Informations de copyright
© 2024. The Author(s).
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