A high-efficiency and selective fluorescent assay for the detection of tetracyclines.
4-fluororesorcinol, Turn-off detection, Environment and food
Dopamine
Fluorescent assay
Tetracyclines
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
30
05
2024
accepted:
25
09
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
2
10
2024
Statut:
epublish
Résumé
Tetracyclines (TCs) rank second globally in the use of animal infection therapy and animal husbandry as growth promoters among all antibiotics. However, large amounts of TCs residue in food products and more than 75% of TCs are excreted into the environment, causing adverse effects on the ecological system and human health. It has been challenging to simultaneously realize low-cost, rapid, and highly selective detection of TCs. Here, inspired by the fluorogenic reactions between resorcinol and catecholamines, we find the fluorescence quenching ability of tetracycline (TC) and firstly propose a fluorescent "turn-off" detection of TC using dopamine and 4-fluororesorcinol. The optimal reaction condition for the fluorescent assay is investigated and the optimized probe showed a good limit of detection (LOD of 1.7 µM) and a wide linear range (10 µM to 350 µM). Moreover, this fluorescent assay proved to be an effective tool for detecting TC in river, Sprite, and beer samples, which represent the aquatic environments and food and may contain tetracyclines residues. Finally, the high selectivity of the method for TC has been confirmed by eliminating the interference from common substances. The proposed strategy provides a high-efficiency and selective solution for the detection of TCs in environment and food and the application fields of this fluorescent assay could be further expanded in the future.
Identifiants
pubmed: 39358472
doi: 10.1038/s41598-024-74411-7
pii: 10.1038/s41598-024-74411-7
doi:
Substances chimiques
Tetracyclines
0
Fluorescent Dyes
0
Dopamine
VTD58H1Z2X
Anti-Bacterial Agents
0
Water Pollutants, Chemical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22918Subventions
Organisme : Shandong Provincial Natural Science Foundation
ID : ZR2023QF170
Organisme : Shandong Provincial Natural Science Foundation
ID : ZR2023QF174
Organisme : Shandong Provincial Natural Science Foundation
ID : ZR2023QB125
Organisme : Shandong Provincial Natural Science Foundation
ID : ZR2023QB232
Organisme : Scientific Research Fund of Dezhou University
ID : 2022xjrc404
Organisme : Scientific Research Fund of Dezhou University
ID : 2022xjrc205
Organisme : Scientific Research Fund of Dezhou University
ID : 2019xjrc211
Organisme : Scientific Research Fund of Dezhou University
ID : 2022xjrc201
Organisme : Scientific Research Fund of Dezhou University
ID : 2022xjrc421
Organisme : National Natural Science Foundation of China
ID : 32071392
Informations de copyright
© 2024. The Author(s).
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