Early B lymphocyte subsets in blood predict prognosis in sepsis.
B cell subset
B lymphocytes
CD5+ B cells
double-negative B cells
flow cytometry
innate immune
prognosis
sepsis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
24
05
2024
accepted:
28
08
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
3
10
2024
Statut:
epublish
Résumé
B lymphocytes play a key role in immunosuppression. This study investigated the prognostic value of B cell subsets in sepsis. Flow cytometry was used to assess peripheral B cell subsets from patients with sepsis on the first and seventh days following admission, as well as 111 healthy controls. The patients were divided into survivors and non-survivors, based on 28-day prognosis. The analysis showed abnormal distribution and selective depletion of B cells and its subsets in the early stages of sepsis. On day 1, compared with survivors, non-survivors showed significant decreases in the proportion and absolute count of transitional (Tr) B cells, reductions in the proportion of CD5 Our study revealed that deficiencies of B, Tr B, and CD5
Sections du résumé
Background
UNASSIGNED
B lymphocytes play a key role in immunosuppression. This study investigated the prognostic value of B cell subsets in sepsis.
Methods
UNASSIGNED
Flow cytometry was used to assess peripheral B cell subsets from patients with sepsis on the first and seventh days following admission, as well as 111 healthy controls. The patients were divided into survivors and non-survivors, based on 28-day prognosis.
Results
UNASSIGNED
The analysis showed abnormal distribution and selective depletion of B cells and its subsets in the early stages of sepsis. On day 1, compared with survivors, non-survivors showed significant decreases in the proportion and absolute count of transitional (Tr) B cells, reductions in the proportion of CD5
Conclusion
UNASSIGNED
Our study revealed that deficiencies of B, Tr B, and CD5
Identifiants
pubmed: 39359725
doi: 10.3389/fimmu.2024.1437864
pmc: PMC11445034
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1437864Informations de copyright
Copyright © 2024 Sun, Lu, Pan, Zhang, Wang and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.