Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in
JAK-STAT signaling pathway
Leishmania tropica
cutaneous leishmaniasis
cytokines
immune checkpoints
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
21
05
2024
accepted:
02
09
2024
medline:
4
10
2024
pubmed:
4
10
2024
entrez:
4
10
2024
Statut:
epublish
Résumé
The JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathway in human cutaneous leishmaniasis (CL) due to This study sought to investigate differential gene expression of several cytokines and their associated Results showed that the gene expression levelsof both Th1 ( Our finding revealed dysregulation of cytokines and related
Sections du résumé
Background
UNASSIGNED
The JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathway in human cutaneous leishmaniasis (CL) due to
Methods
UNASSIGNED
This study sought to investigate differential gene expression of several cytokines and their associated
Results
UNASSIGNED
Results showed that the gene expression levelsof both Th1 (
Conclusion
UNASSIGNED
Our finding revealed dysregulation of cytokines and related
Identifiants
pubmed: 39364404
doi: 10.3389/fimmu.2024.1436029
pmc: PMC11446769
doi:
Substances chimiques
STAT Transcription Factors
0
Cytokines
0
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1436029Informations de copyright
Copyright © 2024 Hadifar, Masoudzadeh, Heydari, Mashayekhi Goyonlo, Kerachian, Daneshpazhooh, Sadeghnia, Tootoonchi, Erfanian Salim, Rafati and Harandi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.