Change in Nfkb/Nrf2/Bax Levels by High Monomeric Polyphenols Berries Extract (HMPBE) in Acute and Chronic Secondary Brain Damage.
Animals
NF-E2-Related Factor 2
/ metabolism
Polyphenols
/ pharmacology
Mice
NF-kappa B
/ metabolism
Male
Plant Extracts
/ pharmacology
Fruit
/ chemistry
bcl-2-Associated X Protein
/ metabolism
Brain Injuries, Traumatic
/ metabolism
Disease Models, Animal
Tyrosine 3-Monooxygenase
/ metabolism
Dopamine Plasma Membrane Transport Proteins
/ metabolism
Apoptosis
/ drug effects
Mice, Inbred C57BL
Brain
/ metabolism
Lipid Peroxidation
/ drug effects
Nrf-2 ; Oxidative stress ; Neuroinflammation ; Brain damages ; HMPBE
Journal
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
ISSN: 1421-9778
Titre abrégé: Cell Physiol Biochem
Pays: Germany
ID NLM: 9113221
Informations de publication
Date de publication:
06 Oct 2024
06 Oct 2024
Historique:
accepted:
17
09
2024
medline:
7
10
2024
pubmed:
7
10
2024
entrez:
7
10
2024
Statut:
ppublish
Résumé
High Monomeric Polyphenols Berries Extract (HMPBE) is a formula highly rich in polyphenols clinically proven to enhance learning and memory. It is currently used to enhances cognitive performance including accuracy, working memory and concentration. Here, we investigated for the first time the beneficial effects of HMPBE in a mouse model of acute and chronic traumatic brain injury (TBI). HMPBE, at the dose of 15 mg/kg was able to reduce histological alteration as well as inflammation and lipid peroxidation. HMPBE ameliorate TBI by improving Nrf-2 pathway, reducing Nf-kb nuclear translocation and apoptosis, and ameliorating behavioral alteration such as anxiety and depression. Moreover, in the chronic model of TBI, HMPBE administration restored the decline of Tyrosine Hydroxylase (TH) and dopamine transporter (DAT) and the accumulation of a-synuclein into the midbrain region. This finding correlates the beneficial effect of HMPBE administration with the onset of parkinsonism related to traumatic brain damage. The data may open a window for developing new support strategies to limit the neuroinflammation event of acute and chronic TBI.
Sections du résumé
BACKGROUND/AIMS
OBJECTIVE
High Monomeric Polyphenols Berries Extract (HMPBE) is a formula highly rich in polyphenols clinically proven to enhance learning and memory. It is currently used to enhances cognitive performance including accuracy, working memory and concentration.
METHODS
METHODS
Here, we investigated for the first time the beneficial effects of HMPBE in a mouse model of acute and chronic traumatic brain injury (TBI).
RESULTS
RESULTS
HMPBE, at the dose of 15 mg/kg was able to reduce histological alteration as well as inflammation and lipid peroxidation. HMPBE ameliorate TBI by improving Nrf-2 pathway, reducing Nf-kb nuclear translocation and apoptosis, and ameliorating behavioral alteration such as anxiety and depression. Moreover, in the chronic model of TBI, HMPBE administration restored the decline of Tyrosine Hydroxylase (TH) and dopamine transporter (DAT) and the accumulation of a-synuclein into the midbrain region. This finding correlates the beneficial effect of HMPBE administration with the onset of parkinsonism related to traumatic brain damage.
CONCLUSION
CONCLUSIONS
The data may open a window for developing new support strategies to limit the neuroinflammation event of acute and chronic TBI.
Substances chimiques
NF-E2-Related Factor 2
0
Polyphenols
0
NF-kappa B
0
Plant Extracts
0
bcl-2-Associated X Protein
0
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Dopamine Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
548-570Subventions
Organisme : University of Catania
ID : MUR PRIN 2022FWB4EX
Pays : Italy
Organisme : Ministry of Education in Saudi Arabia, King Saud University
ID : RSPD2024R750
Pays : Saudi Arabia
Informations de copyright
© Copyright by the Author(s). Published by Cell Physiol Biochem Press.
Déclaration de conflit d'intérêts
The authors have no relevant financial or non-financial interests to disclose.