Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition:

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
08 Oct 2024
Historique:
medline: 8 10 2024
pubmed: 8 10 2024
entrez: 8 10 2024
Statut: aheadofprint

Résumé

The benzoxaborinine scaffold, a homologue of benzoxaborole with an additional carbon atom in the boracycle, shows significant potential in developing new therapeutic agents. This study reports the synthesis, inhibition assays against four human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, and anti-melanoma evaluation of 7-aryl(thio)ureido-substituted benzoxaborinines. Some derivatives, particularly compound

Identifiants

DOI: 10.1021/acs.jmedchem.4c01516 PMID: 39378331
pubmed: 39378331
doi: 10.1021/acs.jmedchem.4c01516
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Simone Giovannuzzi (S)

IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France.
Department of NEUROFARBA - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Sesto Fiorentino, Firenze, Italy.

Anna Nikitjuka (A)

IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France.
Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.

Andrea Angeli (A)

Department of NEUROFARBA - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Sesto Fiorentino, Firenze, Italy.
ORCID: 0000-0002-1470-7192

Michael Smietana (M)

IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France.
ORCID: 0000-0001-8132-7221

Maria-Luisa Massardi (ML)

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.

Marta Turati (M)

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.

Roberto Ronca (R)

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.

Alessandro Bonardi (A)

Department NEUROFARBA, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

Alessio Nocentini (A)

Department of NEUROFARBA - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Sesto Fiorentino, Firenze, Italy.
ORCID: 0000-0003-3342-702X

Marta Ferraroni (M)

Department of Chemistry "Ugo Schiff" (DICUS), University of Florence, 50019 Sesto Fiorentino, Firenze, Italy.
ORCID: 0000-0001-7258-738X

Claudiu T Supuran (CT)

Department of NEUROFARBA - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Sesto Fiorentino, Firenze, Italy.
ORCID: 0000-0003-4262-0323

Jean-Yves Winum (JY)

IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France.
ORCID: 0000-0003-3197-3414

Classifications MeSH