Construction of in-situ self-assembled agent for NIR/PET dual-modal imaging and photodynamic therapy for hepatocellular cancer.
Photochemotherapy
/ methods
Animals
Humans
Liver Neoplasms
/ drug therapy
Carcinoma, Hepatocellular
/ diagnostic imaging
Hep G2 Cells
Mice
Positron-Emission Tomography
/ methods
Mice, Nude
Mice, Inbred BALB C
Disaccharides
/ chemistry
Tissue Distribution
Photosensitizing Agents
/ chemistry
Fluorine Radioisotopes
/ chemistry
Optical Imaging
/ methods
ASGPR
In-situ self-assembly
Lactobionic acid
PET imaging
Photodynamic therapy
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
10 Oct 2024
10 Oct 2024
Historique:
received:
28
04
2024
accepted:
26
09
2024
medline:
10
10
2024
pubmed:
10
10
2024
entrez:
10
10
2024
Statut:
epublish
Résumé
Hepatocellular cancer (HCC) remained a life-threatening carcinoma. Agents for HCC imaging and therapy were expected to possess different intratumoral retention time. To construct an agent with different intratumoral retention time when applied for tumor imaging or therapy remained great values. A lasialoglycoprotein receptor (ASGPR) targeted lactobionic acid derivative (LABO) was constructed for fluorescent imaging and photodynamic therapy of HCC.
Identifiants
pubmed: 39385303
doi: 10.1186/s12951-024-02879-6
pii: 10.1186/s12951-024-02879-6
doi:
Substances chimiques
lactobionic acid
65R938S4DV
Disaccharides
0
Photosensitizing Agents
0
Fluorine Radioisotopes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
614Subventions
Organisme : National Natural Science Foundation of China
ID : 81974271
Informations de copyright
© 2024. The Author(s).
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