Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension.

adoptive transfer hypoxia macrophage activation pulmonary arterial hypertension vascular remodeling

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
10 Oct 2024
Historique:
medline: 10 10 2024
pubmed: 10 10 2024
entrez: 10 10 2024
Statut: aheadofprint

Résumé

Macrophages play a significant role in the onset and progression of vascular disease in pulmonary hypertension, and cell-based immunotherapies aimed at treating vascular remodeling are lacking. To evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/proresolving phenotype in attenuating early pulmonary inflammation and progression of experimentally induced pulmonary hypertension. Mouse bone marrow-derived macrophages were polarized in vitro to a regulatory (M2 M2 Adoptive transfer of M2

Sections du résumé

BACKGROUND UNASSIGNED
Macrophages play a significant role in the onset and progression of vascular disease in pulmonary hypertension, and cell-based immunotherapies aimed at treating vascular remodeling are lacking. To evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/proresolving phenotype in attenuating early pulmonary inflammation and progression of experimentally induced pulmonary hypertension.
METHODS UNASSIGNED
Mouse bone marrow-derived macrophages were polarized in vitro to a regulatory (M2
RESULTS UNASSIGNED
M2
CONCLUSIONS UNASSIGNED
Adoptive transfer of M2

Identifiants

DOI: 10.1161/ATVBAHA.124.321264 PMID: 39387119
pubmed: 39387119
doi: 10.1161/ATVBAHA.124.321264
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Angeles Fernandez-Gonzalez (A)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).
ORCID: 0000-0003-1219-9128

Amit Mukhia (A)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).

Janhavi Nadkarni (J)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).

Gareth R Willis (GR)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).
ORCID: 0000-0002-7302-8261

Monica Reis (M)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).

Kristjan Zhumka (K)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).

Sally Vitali (S)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Division of Critical Care Medicine, Department of Anesthesia, Perioperative, and Pain Medicine, Boston Children's Hospital, MA. (S.V.).
ORCID: 0000-0002-8221-4453

Xianlan Liu (X)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).

Alexandra Galls (A)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).
ORCID: 0000-0003-2720-169X

S Alex Mitsialis (SA)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).
ORCID: 0000-0001-8315-7828

Stella Kourembanas (S)

Division of Newborn Medicine, Boston Children's Hospital, MA. (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., S.V., X.L., A.G., S.A.M., S.K.).
Department of Pediatrics, Harvard Medical School, Boston, MA (A.F.-G., A.M., J.N., G.R.W., M.R., K.Z., X.L., A.G., S.A.M., S.K.).
ORCID: 0000-0002-4791-9589

Classifications MeSH