Biologics in Hypereosinophilic Syndrome and Eosinophilic Granulomatosis with Polyangiitis.

Humans Hypereosinophilic Syndrome / diagnosis Biological Products / therapeutic use Granulomatosis with Polyangiitis / diagnosis Eosinophils / immunology Treatment Outcome
Benralizumab Biologic therapy Dupilumab Eosinophilia Eosinophilic granulomatosis with polyangiitis Hypereosinophilic syndrome Mepolizumab Reslizumab

Journal

Immunology and allergy clinics of North America
ISSN: 1557-8607
Titre abrégé: Immunol Allergy Clin North Am
Pays: United States
ID NLM: 8805635

Informations de publication

Date de publication:
Nov 2024
Historique:
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 10 10 2024
Statut: ppublish

Résumé

Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA) are complex disorders defined by blood and tissue eosinophilia and heterogeneous clinical manifestations. Historically, the mainstay of therapy for both conditions has been systemic glucocorticoids. However, recent availability of biologics that directly or indirectly target eosinophils has provided new avenues to pursue improved outcomes with decreased toxicity. In this article, we summarize the evidence supporting the use of specific biologics in HES and/or EGPA and provide a framework for their clinical use in patients.

Identifiants

DOI: 10.1016/j.iac.2024.07.003 PMID: 39389714
pubmed: 39389714
pii: S0889-8561(24)00052-3
doi: 10.1016/j.iac.2024.07.003
pii:
doi:

Substances chimiques

Biological Products 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

629-644

Subventions

Organisme : Intramural NIH HHS
ID : ZIA AI001130
Pays : United States

Informations de copyright

Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose. This work was supported in part by the Division of Intramural Research, NIAID, NIH.

Auteurs

Ejiofor Ezekwe (E)

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B1-28, 4 Memorial Drive, Bethesda, MD 20892, USA.

Andrew L Weskamp (AL)

National Capital Consortium Allergy & Immunology ellowship, Department of Medicine, Allergy & Immunology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Luke M Pittman (LM)

National Capital Consortium Allergy & Immunology ellowship, Department of Medicine, Allergy & Immunology Service, Walter Reed National Military Medical Center, 8300 Wisconsin Avenue, Apartment 632, Bethesda, MD 20814, USA.

Amy D Klion (AD)

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B1-28, 4 Memorial Drive, Bethesda, MD 20892, USA. Electronic address: amy.klion@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biologics in Hypereosinophilic Syndrome and...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Troubles leucocytaires › Éosinophilie › Syndrome hyperéosinophilique › Biologics in Hypereosinophilic Syndrome and...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Biologics in Hypereosinophilic Syndrome and...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Granulomatose avec polyangéite › Biologics in Hypereosinophilic Syndrome and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes éosinophiles › Biologics in Hypereosinophilic Syndrome and...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Biologics in Hypereosinophilic Syndrome and...