Shank3 mutation impairs glutamate signaling and myelination in ASD mouse model and human iPSC-derived OPCs.

Animals Induced Pluripotent Stem Cells / metabolism Humans Nerve Tissue Proteins / genetics Mice Oligodendroglia / metabolism Disease Models, Animal Myelin Sheath / metabolism Glutamic Acid / metabolism Autism Spectrum Disorder / genetics Mutation Signal Transduction Microfilament Proteins / genetics

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
11 Oct 2024
Historique:
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 11 10 2024
Statut: ppublish

Résumé

Autism spectrum disorder (ASD) is characterized by social and neurocognitive impairments, with mutations of the

Identifiants

DOI: 10.1126/sciadv.adl4573 PMID: 39392881
pubmed: 39392881
doi: 10.1126/sciadv.adl4573
doi:

Substances chimiques

Nerve Tissue Proteins 0
Glutamic Acid 3KX376GY7L
SHANK3 protein, human 0
Shank3 protein, mouse 0
Microfilament Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadl4573

Auteurs

Inbar Fischer (I)

The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0009-0005-4915-2114

Sophie Shohat (S)

The School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel.
The School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Yael Leichtmann-Bardoogo (Y)

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0003-1130-5064

Ritu Nayak (R)

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.

Gal Wiener (G)

The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Idan Rosh (I)

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.

Aviram Shemen (A)

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
ORCID: 0009-0001-0493-9803

Utkarsh Tripathi (U)

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
ORCID: 0000-0001-9503-3793

May Rokach (M)

The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0009-0009-9226-7653

Ela Bar (E)

The School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel.
The School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Yara Hussein (Y)

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
ORCID: 0000-0001-6173-8584

Ana Carolina Castro (AC)

Department of Biomedicine-Experimental Biology Unit, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal.
ORCID: 0009-0007-4430-163X

Gal Chen (G)

The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion, Haifa, Israel.
The Interdisciplinary Program for Biotechnology, Technion, Haifa, Israel.

Adi Soffer (A)

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.

Sari Schokoroy-Trangle (S)

The School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel.

Galit Elad-Sfadia (G)

The School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel.

Yaniv Assaf (Y)

The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
The School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
The Strauss Center for Neuroimaging, Tel Aviv University, Tel Aviv, Israel.

Avi Schroeder (A)

The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion, Haifa, Israel.
ORCID: 0000-0003-2571-5937

Patricia Monteiro (P)

Department of Biomedicine-Experimental Biology Unit, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal.
ORCID: 0000-0003-3288-4560

Shani Stern (S)

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
ORCID: 0000-0002-2644-7068

Ben M Maoz (BM)

The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.
Sagol Center for Regenerative Medicine, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0002-3823-7682

Boaz Barak (B)

The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
The School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel.
The School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0001-9724-4578

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Shank3 mutation impairs glutamate signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Shank3 mutation impairs glutamate signaling...