Impact of smokeless tobacco on psychological and oxidative stress in unemployed indian youth.
Humans
Male
Oxidative Stress
/ drug effects
Adult
India
/ epidemiology
Tobacco, Smokeless
Stress, Psychological
Case-Control Studies
Young Adult
Tobacco Use Disorder
/ psychology
Homocysteine
/ blood
Unemployment
/ psychology
Malondialdehyde
/ blood
Superoxide Dismutase
/ metabolism
Catalase
/ metabolism
Homocysteine
India
MDA
Oxidative stress
Psychological stress
SOD
Tobacco
Unemployed youth
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
12 Oct 2024
12 Oct 2024
Historique:
received:
05
11
2023
accepted:
20
08
2024
medline:
13
10
2024
pubmed:
13
10
2024
entrez:
12
10
2024
Statut:
epublish
Résumé
In India, tobacco (nicotine) addiction among youth has increased, leading to substantial socioeconomic burdens, mortality, and morbidity. While minimal short-term nicotine consumption may have antioxidant effects, chronic exposure results in various adverse health outcomes. This study examines the impact of chronic nicotine consumption on cellular oxidative stress and psychological stress, and their correlation with Homocysteine (Hcy) levels in unemployed tobacco consumers. This case-control study included 156 healthy, educated, unemployed male volunteers aged 20-40 years, divided into nicotine-addicted (n = 80) and non-addicted (n = 76) groups. Psychological stress was assessed using perceived stress scales (PSS) and coping self-efficacy (CSE) scales. Oxidative stress markers, including Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Catalase, were measured. Hcy levels were quantified using high-performance liquid chromatography (HPLC). Nicotine-addicted participants exhibited significantly higher perceived stress (p = 0.0001) and lower coping self-efficacy (p = 0.0001) compared to non-addicted individuals. MDA levels in erythrocytes were significantly increased (p = 0.0006), while SOD (p = 0.0001) and Catalase (p = 0.02) activities were significantly decreased in the addicted group. Nicotine intake influenced Hcy concentrations, with 55% of addicted individuals falling into moderate, 27.5% into intermediate, and 7.5% into severe Hcy categories. Chronic nicotine intake also reflected the hematological parameters (WBCs, RBCs, HGB, and Platelets). Chronic tobacco consumption induces oxidative stress and perceived psychological stress, leading to elevated Hcy levels in nicotine consumers. The study highlights the detrimental effects of nicotine addiction on cellular defensive mechanisms, emphasizing the need for targeted interventions to address this growing health issue among unemployed Indian youth.
Identifiants
pubmed: 39395920
doi: 10.1007/s00726-024-03416-3
pii: 10.1007/s00726-024-03416-3
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Malondialdehyde
4Y8F71G49Q
Superoxide Dismutase
EC 1.15.1.1
Catalase
EC 1.11.1.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
59Informations de copyright
© 2024. The Author(s).
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