Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection.
Chronic active Epstein-Barr virus infection
Dysfunction
Epstein-Barr virus
Pediatric
γδ T cells
Journal
Italian journal of pediatrics
ISSN: 1824-7288
Titre abrégé: Ital J Pediatr
Pays: England
ID NLM: 101510759
Informations de publication
Date de publication:
12 Oct 2024
12 Oct 2024
Historique:
received:
01
07
2024
accepted:
02
10
2024
medline:
13
10
2024
pubmed:
13
10
2024
entrez:
12
10
2024
Statut:
epublish
Résumé
Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients. A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease.
Identifiants
pubmed: 39396033
doi: 10.1186/s13052-024-01783-x
pii: 10.1186/s13052-024-01783-x
doi:
Substances chimiques
Receptors, Antigen, T-Cell, gamma-delta
0
Granzymes
EC 3.4.21.-
Types de publication
Journal Article
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
213Informations de copyright
© 2024. The Author(s).
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