Parallel evolution of fluconazole resistance and tolerance in
Candida glabrata
/ drug effects
Fluconazole
/ pharmacology
Drug Resistance, Fungal
/ genetics
Antifungal Agents
/ pharmacology
Microbial Sensitivity Tests
Temperature
Candida albicans
/ drug effects
Calcineurin
/ metabolism
HSP90 Heat-Shock Proteins
/ genetics
Fungal Proteins
/ genetics
Drug Tolerance
Mutation
Candida glabrata
Hsp90
antifungal resistance
antifungal tolerance
calcineurin
evolution trajectory
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2024
2024
Historique:
received:
29
06
2024
accepted:
11
09
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
14
10
2024
Statut:
epublish
Résumé
With the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. This study investigates how This study compared the factors regulating fluconazole tolerance between We found temperature modulated tolerance in the opposite way in This study highlights that while tolerance to fluconazole is a common response in
Identifiants
pubmed: 39397866
doi: 10.3389/fcimb.2024.1456907
pmc: PMC11466938
doi:
Substances chimiques
Fluconazole
8VZV102JFY
Antifungal Agents
0
Calcineurin
EC 3.1.3.16
HSP90 Heat-Shock Proteins
0
Fungal Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1456907Informations de copyright
Copyright © 2024 Zheng, Xu, Wang, Dong and Guo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.