Adenosine Metabolism Pathway Alterations in Frontal Cortical Neurons in Schizophrenia.
Humans
Schizophrenia
/ metabolism
Adenosine
/ metabolism
Female
Male
Adenosine Kinase
/ metabolism
Neurons
/ metabolism
Middle Aged
Frontal Lobe
/ metabolism
5'-Nucleotidase
/ metabolism
Aged
RNA, Messenger
/ metabolism
Equilibrative Nucleoside Transporter 1
/ metabolism
Adult
Apyrase
/ metabolism
Case-Control Studies
GPI-Linked Proteins
adenosine kinase
anterior cingulate cortex
ecto-5′-nucleotidases
ectonucleoside triphosphate diphosphohydrolases
equilibrative nucleoside transporters
neuromodulation
pyramidal neurons
schizophrenia
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 Oct 2024
06 Oct 2024
Historique:
received:
11
09
2024
revised:
01
10
2024
accepted:
04
10
2024
medline:
15
10
2024
pubmed:
15
10
2024
entrez:
15
10
2024
Statut:
epublish
Résumé
Schizophrenia is a neuropsychiatric illness characterized by altered neurotransmission, in which adenosine, a modulator of glutamate and dopamine, plays a critical role that is relatively unexplored in the human brain. In the present study, postmortem human brain tissue from the anterior cingulate cortex (ACC) of individuals with schizophrenia (
Identifiants
pubmed: 39404420
pii: cells13191657
doi: 10.3390/cells13191657
pii:
doi:
Substances chimiques
Adenosine
K72T3FS567
Adenosine Kinase
EC 2.7.1.20
5'-Nucleotidase
EC 3.1.3.5
RNA, Messenger
0
Equilibrative Nucleoside Transporter 1
0
NT5E protein, human
EC 3.1.3.5
Apyrase
EC 3.6.1.5
GPI-Linked Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : MH107487
Pays : United States
Organisme : American Foundation of Suicide Prevention
ID : YIG-1-139-20