Comparative Study of Prebiotics for Infants Using a Fecal Culture System: Insights into Responders and Non-Responders.
bifidobacteria
human-residential bifidobacteria
infant formula
non-digestible oligosaccharide
non-responder
prebiotics
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
17
09
2024
revised:
26
09
2024
accepted:
27
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
The gut microbiota of breast-fed infants is dominated by infant-type human-residential bifidobacteria (HRB) that contribute to infant health; thus, it is crucial to develop infant formulas that promote the establishment of a gut microbiota enriched with infant-type HRB, closely resembling that of breastfed infants. We compared various non-digestible prebiotic oligosaccharides and their combinations using a fecal culture system to explore which candidates could promote the growth of all infant-type HRB and rarely yield non-responders. The analysis included lactulose (LAC), raffinose (RAF), galactooligosaccharides (GOS), and short- and long-chain fructooligosaccharides. Fecal samples were collected from seven infants aged 1.5-10.2 months and cultured with each oligosaccharide individually or their combinations. No single oligosaccharide effectively promoted the growth of all infant-type HRB, although GOS promoted the growth of HRB other than This study can aid in developing infant formulas that help align the gut microbiota of formula-fed infants with that of breastfed infants.
Sections du résumé
BACKGROUND
BACKGROUND
The gut microbiota of breast-fed infants is dominated by infant-type human-residential bifidobacteria (HRB) that contribute to infant health; thus, it is crucial to develop infant formulas that promote the establishment of a gut microbiota enriched with infant-type HRB, closely resembling that of breastfed infants.
METHODS
METHODS
We compared various non-digestible prebiotic oligosaccharides and their combinations using a fecal culture system to explore which candidates could promote the growth of all infant-type HRB and rarely yield non-responders. The analysis included lactulose (LAC), raffinose (RAF), galactooligosaccharides (GOS), and short- and long-chain fructooligosaccharides. Fecal samples were collected from seven infants aged 1.5-10.2 months and cultured with each oligosaccharide individually or their combinations.
RESULTS
RESULTS
No single oligosaccharide effectively promoted the growth of all infant-type HRB, although GOS promoted the growth of HRB other than
CONCLUSIONS
CONCLUSIONS
This study can aid in developing infant formulas that help align the gut microbiota of formula-fed infants with that of breastfed infants.
Identifiants
pubmed: 39408314
pii: nu16193347
doi: 10.3390/nu16193347
pii:
doi:
Substances chimiques
Prebiotics
0
Oligosaccharides
0
fructooligosaccharide
0
Lactulose
4618-18-2
Raffinose
N5O3QU595M
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM