Evidence of Neutrophils and Neutrophil Extracellular Traps in Human NMSC with Regard to Clinical Risk Factors, Ulceration and CD8
Humans
Extracellular Traps
/ metabolism
Neutrophils
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Skin Neoplasms
/ immunology
Male
Aged
Carcinoma, Basal Cell
/ immunology
Carcinoma, Squamous Cell
/ immunology
Female
Risk Factors
Middle Aged
Carcinoma, Merkel Cell
/ immunology
Aged, 80 and over
Neutrophil Infiltration
Lymphocytes, Tumor-Infiltrating
/ immunology
Merkel cell carcinoma
basal cell carcinoma
cutaneous squamous cell carcinoma
cytotoxic T cells
neutrophil extracellular traps
neutrophils
non-melanoma skin cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
22
08
2024
revised:
24
09
2024
accepted:
26
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
Non-melanoma skin cancers (NMSC), including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and Merkel cell carcinoma (MCC), are increasingly common and present significant healthcare challenges. Neutrophil extracellular traps (NETs), chromatin fibers expulsed by neutrophil granulocytes, can promote immunotherapy resistance via an impairment of CD8
Identifiants
pubmed: 39408949
pii: ijms251910620
doi: 10.3390/ijms251910620
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Muenster, Medical Faculty, Medizinerkolleg
ID : 22-0030