Directly monitoring the dynamic in vivo metabolisms of hyperpolarized

Animals Mice Carbon Isotopes Oligopeptides / metabolism Kidney / metabolism Magnetic Resonance Spectroscopy / methods

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
18 Oct 2024
Historique:
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: ppublish

Résumé

Peptides play essential roles in biological phenomena, and, thus, there is a growing interest in detecting in vivo dynamics of peptide metabolisms. Dissolution-dynamic nuclear polarization (d-DNP) is a state-of-the-art technology that can markedly enhance the sensitivity of nuclear magnetic resonance (NMR), providing metabolic and physiological information in vivo. However, the hyperpolarized state exponentially decays back to the thermal equilibrium, depending on the spin-lattice relaxation time (

Identifiants

DOI: 10.1126/sciadv.adp2533 PMID: 39413185
pubmed: 39413185
doi: 10.1126/sciadv.adp2533
doi:

Substances chimiques

Carbon Isotopes 0
Oligopeptides 0
Carbon-13 FDJ0A8596D

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadp2533

Auteurs

Yohei Kondo (Y)

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0003-2750-6661

Yutaro Saito (Y)

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0001-7610-121X

Tomohiro Seki (T)

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Yoichi Takakusagi (Y)

Quantum Hyperpolarized MRI Research Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.
Institute for Quantum Medical Science (iQMS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.
Department of Quantum Life Science, Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage, Chiba-city 265-8522, Japan.
ORCID: 0000-0002-6786-0748

Norikazu Koyasu (N)

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Keita Saito (K)

Quantum Hyperpolarized MRI Research Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.

Jumpei Morimoto (J)

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0002-8393-9616

Hiroshi Nonaka (H)

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0003-4623-2926

Koichiro Miyanishi (K)

Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
Center for Quantum Information and Quantum Biology, Osaka University, Osaka 560-8531, Japan.

Wataru Mizukami (W)

Center for Quantum Information and Quantum Biology, Osaka University, Osaka 560-8531, Japan.
ORCID: 0000-0003-3538-3542

Makoto Negoro (M)

Quantum Hyperpolarized MRI Research Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage, Chiba-city 263-8555, Japan.
Center for Quantum Information and Quantum Biology, Osaka University, Osaka 560-8531, Japan.
Premium Research Institute for Human Metaverse Medicine, Osaka University, Toyonaka, Osaka 560-0043, Japan.
ORCID: 0000-0003-3482-3198

Abdelazim E Elhelaly (AE)

Department of Radiology, Frontier Science for Imaging, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
ORCID: 0000-0001-6191-3194

Fuminori Hyodo (F)

Department of Pharmacology, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
Center for One Medicine Innovative Translational Research (COMIT), Gifu University, 501-1194, Gifu, Japan.

Masayuki Matsuo (M)

Department of Radiology, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.

Natarajan Raju (N)

Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.
ORCID: 0009-0002-5059-2246

Rolf E Swenson (RE)

Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.
ORCID: 0000-0001-7804-7202

Murali C Krishna (MC)

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0002-7216-7788

Kazutoshi Yamamoto (K)

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0001-9405-5421

Shinsuke Sando (S)

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0003-0275-7237

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Directly monitoring the dynamic in vivo...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Directly monitoring the dynamic in vivo...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Isotopes du carbone › Directly monitoring the dynamic in vivo...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Directly monitoring the dynamic in vivo...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Directly monitoring the dynamic in vivo...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Directly monitoring the dynamic in vivo...