OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1
Phosphorylation
Tripartite Motif-Containing Protein 28
/ metabolism
Ataxia Telangiectasia Mutated Proteins
/ metabolism
Telomere
/ metabolism
Humans
DNA End-Joining Repair
DNA Damage
Ubiquitin-Protein Ligases
/ metabolism
Heterochromatin
/ metabolism
Endopeptidases
/ metabolism
HEK293 Cells
Ubiquitination
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 Oct 2024
17 Oct 2024
Historique:
received:
15
12
2023
accepted:
08
10
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
17
10
2024
Statut:
epublish
Résumé
Appropriate repair of damaged DNA and the suppression of DNA damage responses at telomeres are essential to preserve genome stability. DNA damage response (DDR) signaling consists of cascades of kinase-driven phosphorylation events, fine-tuned by proteolytic and regulatory ubiquitination. It is not fully understood how crosstalk between these two major classes of post-translational modifications impact DNA repair at deprotected telomeres. Hence, we performed a functional genetic screen to search for ubiquitin system factors that promote KAP1
Identifiants
pubmed: 39420004
doi: 10.1038/s41467-024-53404-0
pii: 10.1038/s41467-024-53404-0
doi:
Substances chimiques
Tripartite Motif-Containing Protein 28
EC 2.3.2.27
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
TRIM28 protein, human
EC 2.3.2.27
OTUD5 protein, human
EC 3.4.-
ATM protein, human
EC 2.7.11.1
Ubiquitin-Protein Ligases
EC 2.3.2.27
Heterochromatin
0
Endopeptidases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8960Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions)
ID : 812829
Organisme : KWF Kankerbestrijding (Dutch Cancer Society)
ID : 2019-2/12826
Organisme : KWF Kankerbestrijding (Dutch Cancer Society)
ID : institutional grant to the Netherlands Cancer Institute
Organisme : Dutch Ministry of Health, Welfare and Sport | Rijksinstituut voor Volksgezondheid en Milieu (Netherlands National Institute for Public Health and the Environment)
ID : Institutional grant to the Netherlands Cancer Institute
Informations de copyright
© 2024. The Author(s).
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