Low blood S-methyl-5-thioadenosine is associated with postoperative delayed neurocognitive recovery.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
20 Oct 2024
20 Oct 2024
Historique:
received:
19
01
2024
accepted:
15
10
2024
medline:
21
10
2024
pubmed:
21
10
2024
entrez:
20
10
2024
Statut:
epublish
Résumé
Elderly individuals display metabolite alterations that may contribute to development of cognitive impairment following surgery and anesthesia. However, these relationships remain largely unexplored. The study aims to assess the S-methyl-5-thioadenosine (MTA) is associated with postoperative delayed neurocognitive recovery (dNCR). We assess altered metabolites following anesthesia/surgery in both mice and patients to identify blood biomarkers of dNCR. Preoperative and postoperative plasma metabolites are determined by widely targeted metabolomics. The brains of mice with anesthesia/surgery show decreased MTA and activated MTA phosphorylase. Mice also show that preoperative administration of MTA can prevent inflammation and cognitive decline. In clinical patients, we detect lower preoperative serum MTA levels in those who developed dNCR. Both low preoperative and postoperative blood MTA levels are associated with increased risk of postoperative dNCR. These results suggest that anesthesia/surgery induces cognitive decline through methionine synthesis pathways and that MTA could be a perioperative predictor of dNCR.
Identifiants
pubmed: 39428444
doi: 10.1038/s42003-024-07086-5
pii: 10.1038/s42003-024-07086-5
doi:
Substances chimiques
Thionucleosides
0
Biomarkers
0
5'-methylthioadenosine
634Z2VK3UQ
Deoxyadenosines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1356Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82471280
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82071177
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81970990
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82171173
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82371276
Organisme : Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality)
ID : 21dz1200203
Organisme : Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality)
ID : 22ZR1437200
Organisme : Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality)
ID : 22YF1422500
Informations de copyright
© 2024. The Author(s).
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