A comparison of haploidentical versus HLA-identical sibling outpatient hematopoietic cell transplantation using reduced intensity conditioning in patients with acute leukemia.
Humans
Transplantation Conditioning
/ methods
Male
Female
Adult
Hematopoietic Stem Cell Transplantation
/ adverse effects
Middle Aged
Siblings
Graft vs Host Disease
/ etiology
Retrospective Studies
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ therapy
Transplantation, Haploidentical
/ adverse effects
Young Adult
Leukemia, Myeloid, Acute
/ therapy
Adolescent
HLA Antigens
/ immunology
Aged
Transplantation, Homologous
Outpatients
Treatment Outcome
Latin America
acute lymphoblastic leukemia
acute myeloblastic leukemia
hematopoietic cell transplant
outpatient transplantation
peripheral blood transplant
reduced-intensity conditioning
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
13
03
2024
accepted:
12
09
2024
medline:
21
10
2024
pubmed:
21
10
2024
entrez:
21
10
2024
Statut:
epublish
Résumé
Hematopoietic cell transplantation (HCT) increases survival for acute leukemia. Outpatient allogeneic HCT reduces costs and increases transplant rates in developing countries. We report outcomes of outpatient HLA-identical and haploidentical HCT in acute leukemia. This single-center retrospective cohort study analyzed 121 adult patients with acute myeloblastic (AML) and acute lymphoblastic leukemia (ALL) receiving an outpatient allogeneic HCT with peripheral blood allografts after reduced-intensity conditioning (RIC) from 2012-2022. There were 81 (67%) haploidentical and 40 (33%) HLA-identical transplants. Complete chimerism (CC) at day +100 was not different in HLA-identical compared to haploidentical HCT (32.5% and 38.2%, Outpatient peripheral blood allogenic HCT after RIC is a valid and effective alternative for adult patients suffering acute myeloblastic or lymphoblastic leukemia in low-income populations.
Sections du résumé
Background
UNASSIGNED
Hematopoietic cell transplantation (HCT) increases survival for acute leukemia. Outpatient allogeneic HCT reduces costs and increases transplant rates in developing countries. We report outcomes of outpatient HLA-identical and haploidentical HCT in acute leukemia.
Methods
UNASSIGNED
This single-center retrospective cohort study analyzed 121 adult patients with acute myeloblastic (AML) and acute lymphoblastic leukemia (ALL) receiving an outpatient allogeneic HCT with peripheral blood allografts after reduced-intensity conditioning (RIC) from 2012-2022.
Results
UNASSIGNED
There were 81 (67%) haploidentical and 40 (33%) HLA-identical transplants. Complete chimerism (CC) at day +100 was not different in HLA-identical compared to haploidentical HCT (32.5% and 38.2%,
Conclusions
UNASSIGNED
Outpatient peripheral blood allogenic HCT after RIC is a valid and effective alternative for adult patients suffering acute myeloblastic or lymphoblastic leukemia in low-income populations.
Identifiants
pubmed: 39430740
doi: 10.3389/fimmu.2024.1400610
pmc: PMC11486716
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1400610Informations de copyright
Copyright © 2024 Jaime-Pérez, Valdespino-Valdes, Gómez-De León, Barragán-Longoria, Dominguez-Villanueva, Cantú-Rodríguez, Gutiérrez-Aguirre and Gómez-Almaguer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.