Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta.
Humans
Amino Acid Transport System ASC
/ metabolism
Pregnancy Proteins
/ metabolism
Female
Pregnancy
Placenta
/ metabolism
Gene Products, env
/ metabolism
Cell Fusion
Trophoblasts
/ metabolism
Amino Acid Transport Systems, Neutral
/ metabolism
Minor Histocompatibility Antigens
/ metabolism
Fusion Regulatory Protein 1, Heavy Chain
Syncytin-1
cell-to-cell fusion
endogenous retrovirus
placenta
viral receptor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
29 Oct 2024
29 Oct 2024
Historique:
medline:
22
10
2024
pubmed:
21
10
2024
entrez:
21
10
2024
Statut:
ppublish
Résumé
Syncytin-1, a human fusogenic protein of retroviral origin, is crucial for placental syncytiotrophoblast formation. To mediate cell-to-cell fusion, Syncytin-1 requires specific interaction with its cognate receptor. Two trimeric transmembrane proteins, Alanine, Serine, Cysteine Transporters 1 and 2 (ASCT1 and ASCT2), were suggested and widely accepted as Syncytin-1 cellular receptors. To quantitatively assess the individual contributions of human ASCT1 and ASCT2 to the fusogenic activity of Syncytin-1, we developed a model system where the
Identifiants
pubmed: 39432789
doi: 10.1073/pnas.2407519121
doi:
Substances chimiques
Amino Acid Transport System ASC
0
syncytin
0
Pregnancy Proteins
0
Gene Products, env
0
SLC1A5 protein, human
0
Amino Acid Transport Systems, Neutral
0
Minor Histocompatibility Antigens
0
SLC3A2 protein, human
0
Fusion Regulatory Protein 1, Heavy Chain
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2407519121Subventions
Organisme : National Insitute of Virology and Bacteriology, Programme EXCELES
ID : LX22NPO2103
Organisme : Czech Academy of Sciences
ID : Praemium Academiae Award 2018
Organisme : Czech Academy of Sciences
ID : RVO 68378050-KAV-NPUI
Organisme : Ministry of Education, Youth, and Sports of the Czech Republic
ID : LM2023052
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.