Finding NEMO in the thymus.

I-kappa B Kinase / metabolism Humans Thymus Gland / metabolism Incontinentia Pigmenti / genetics Autoantibodies / immunology NF-kappa B / metabolism Signal Transduction Animals Interferon Type I / metabolism

Journal

The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R

Informations de publication

Date de publication:
04 Nov 2024
Historique:
medline: 21 10 2024
pubmed: 21 10 2024
entrez: 21 10 2024
Statut: ppublish

Résumé

Rosain et al. (https://doi.org/10.1084/jem.20231152) describe the association between anti-type I interferon autoantibodies and severe viral infections in patients with incontinentia pigmenti and heterozygous loss-of-function NEMO variants, suggesting a role for canonical NF-κB signaling in immune tolerance. The mechanisms behind this selective autoimmunity remain unclear.

Identifiants

DOI: 10.1084/jem.20241590 PMID: 39432904
pubmed: 39432904
pii: 277033
doi: 10.1084/jem.20241590
pii:
doi:

Substances chimiques

I-kappa B Kinase EC 2.7.11.10
IKBKG protein, human 0
Autoantibodies 0
NF-kappa B 0
Interferon Type I 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Kreins and Ocampo-Godinez.

Auteurs

Juan Moises Ocampo-Godinez (JM)

Infection Immunity and Inflammation Research and Teaching Department, University College London Institute of Child Health, London, UK.

Alexandra Y Kreins (AY)

Infection Immunity and Inflammation Research and Teaching Department, University College London Institute of Child Health, London, UK.
Department of Immunology and Gene Therapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
ORCID: 0000-0001-8748-5837

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › I-kappa B Kinase › Finding NEMO in the thymus.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Finding NEMO in the thymus.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Finding NEMO in the thymus.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies génétiques de la peau › Incontinentia pigmenti › Finding NEMO in the thymus.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Finding NEMO in the thymus.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Finding NEMO in the thymus.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Finding NEMO in the thymus.
questionsmedicales.fr › Eucaryotes › Animaux › Finding NEMO in the thymus.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Finding NEMO in the thymus.