Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head.
Autophagy
Collapse
SQSTM1/p62
Steroid-induced necrosis of the femoral head
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 Oct 2024
22 Oct 2024
Historique:
received:
14
04
2024
accepted:
30
08
2024
medline:
23
10
2024
pubmed:
23
10
2024
entrez:
22
10
2024
Statut:
epublish
Résumé
Autophagy is closely associated with the onset and progression of steroid-induced osteonecrosis of the femoral head (SIONFH). SQSTM1/p62 is an important indicator of autophagic activity. The aim of this study was to investigate the role of SQSTM1/p62 in the development of SIONFH. From May 2021 through November 2021, 36 patients diagnosed with SIONFH and 36 healthy controls were recruited for this study. Evaluations included imaging and pathologic assessment of clinical bone tissue, location and level of SQSTM1/p62 expression, plasma SQSTM1/p62 levels, and receiver operating characteristic (ROC) curves. We observed that the expression level of SQSTM1/p62 in bone samples decreased with the Association Research Circulation Osseous (ARCO) phase. Plasma SQSTM1/p62 levels were significantly higher in the SIONFH group compared to healthy controls. Plasma SQSTM1/p62 levels were higher in pre-crash patients than in post-crash patients, and lower plasma SQSTM1/p62 levels were associated with elevated ARCO stage. Plasma SQSTM1/p62 may represent a potential biomarker for different stages during SIONFH. Lower plasma SQSTM1/p62 levels indicate an advanced stage of SIONFH. This study provides new clues for early diagnosis of SIONFH.
Identifiants
pubmed: 39438530
doi: 10.1038/s41598-024-71743-2
pii: 10.1038/s41598-024-71743-2
doi:
Substances chimiques
Sequestosome-1 Protein
0
SQSTM1 protein, human
0
Biomarkers
0
Steroids
0
P62 protein, human
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
24932Subventions
Organisme : National Natural Science Foundation of China
ID : 82004392
Organisme : National Natural Science Foundation of China
ID : 82274544
Organisme : National Natural Science Foundation of China
ID : 81573996
Organisme : the major project of "Double First-class" and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine
ID : 2021XK05
Organisme : the cultivated project of "Double First-class" and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine
ID : 2021XK41
Organisme : the cultivated project of "Double First-class" and High-level University Discipline Collaborative Innovation Team of Guangzhou University of Chinese Medicine
ID : 2021XK46
Organisme : Bijie Science and Technology Bureau 'the open competition project'
ID : no. BST Major Project No.1,2022
Informations de copyright
© 2024. The Author(s).
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