Kidney function, uric acid, and risk of atrial fibrillation: experience from the AMORIS cohort.
Humans
Atrial Fibrillation
/ diagnosis
Uric Acid
/ blood
Female
Male
Glomerular Filtration Rate
Middle Aged
Hyperuricemia
/ blood
Risk Assessment
Sweden
/ epidemiology
Incidence
Kidney
/ physiopathology
Aged
Biomarkers
/ blood
Risk Factors
Time Factors
Creatinine
/ blood
Registries
Kidney Diseases
/ diagnosis
Atrial fibrillation
Cohort study
Hyperuricemia
Kidney function
Uric acid
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
22 Oct 2024
22 Oct 2024
Historique:
received:
18
06
2024
accepted:
07
10
2024
medline:
23
10
2024
pubmed:
23
10
2024
entrez:
22
10
2024
Statut:
epublish
Résumé
Uric acid closely relates to both kidney disease and atrial fibrillation (AF), yet the extent to which it influences the kidney-AF association remains uncertain. We examined the relationship between kidney function and risk of AF, accounting for uric acid levels. A total of 308,509 individuals in the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) cohort were included and their serum creatinine and uric acid were measured during 1985-1996. Ten-year incident AF was identified via linkage with the national registers. Glomerular filtration rate (eGFR) (ml/min/1.73 m Over a mean follow-up of 9.4 years, 10,007 (3.2%) incident AF cases occurred. After adjusting for age, sex, cardiovascular diseases, total cholesterol, triglycerides, and glucose, individuals with low eGFR (< 30 and 30-59 ml/min/1.73 m Uric acid largely accounted for the relationship between eGFR and AF in this study. However, in individuals without hyperuricemia, eGFR in the lowest range (< 30 ml/min/1.73 m
Sections du résumé
BACKGROUND
BACKGROUND
Uric acid closely relates to both kidney disease and atrial fibrillation (AF), yet the extent to which it influences the kidney-AF association remains uncertain. We examined the relationship between kidney function and risk of AF, accounting for uric acid levels.
METHODS
METHODS
A total of 308,509 individuals in the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) cohort were included and their serum creatinine and uric acid were measured during 1985-1996. Ten-year incident AF was identified via linkage with the national registers. Glomerular filtration rate (eGFR) (ml/min/1.73 m
RESULTS
RESULTS
Over a mean follow-up of 9.4 years, 10,007 (3.2%) incident AF cases occurred. After adjusting for age, sex, cardiovascular diseases, total cholesterol, triglycerides, and glucose, individuals with low eGFR (< 30 and 30-59 ml/min/1.73 m
CONCLUSION
CONCLUSIONS
Uric acid largely accounted for the relationship between eGFR and AF in this study. However, in individuals without hyperuricemia, eGFR in the lowest range (< 30 ml/min/1.73 m
Identifiants
pubmed: 39438792
doi: 10.1186/s12872-024-04236-9
pii: 10.1186/s12872-024-04236-9
doi:
Substances chimiques
Uric Acid
268B43MJ25
Biomarkers
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
581Informations de copyright
© 2024. The Author(s).
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