Antibacterial effects and mechanisms of quercetin-β-cyclodextrin complex mediated photodynamic on Escherichia coli O157:H7.
Quercetin
/ pharmacology
Escherichia coli O157
/ drug effects
Anti-Bacterial Agents
/ pharmacology
beta-Cyclodextrins
/ pharmacology
Biofilms
/ drug effects
Hydrogen Peroxide
/ pharmacology
Photosensitizing Agents
/ pharmacology
Spectroscopy, Fourier Transform Infrared
Ultraviolet Rays
Microbial Sensitivity Tests
Microencapsulation
Photodynamic antibacterial
Quercetin
Β-cyclodextrin
Journal
Archives of microbiology
ISSN: 1432-072X
Titre abrégé: Arch Microbiol
Pays: Germany
ID NLM: 0410427
Informations de publication
Date de publication:
23 Oct 2024
23 Oct 2024
Historique:
received:
03
09
2024
accepted:
16
10
2024
revised:
16
10
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
23
10
2024
Statut:
epublish
Résumé
Quercetin is a natural flavonoid with antioxidant, anti-inflammatory, and antibacterial properties. This work aimed to formulate quercetin-cyclodextrin microcapsules (QT-β-CD) while examining their photodynamic antibacterial effects and underlying mechanisms in detail. Characterization of the QT-β-CD was conducted using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The bacteriostatic effects of UV-A irradiation on Escherichia coli O157:H7 (E. coli O157:H7) were investigated. The photodynamic impact of QT-β-CD was assessed by analyzing hydrogen peroxide (H₂O₂) production. The antimicrobial activity was further elucidated through examinations of cell membrane integrity, protein damage, changes in cellular motility, biofilm formation, and extracellular polysaccharide reduction. The effect of QT-β-CD on LuxS and motA gene expression in E. coli O157:H7 was investigated by RT-qPCR. The findings demonstrated that QT-β-CD exhibited potent photodynamic properties and functioned as an efficient photosensitizer, causing substantial damage to E. coli O157:H7 cells. These results underscore the potential of quercetin as an antimicrobial agent for food preservation.
Identifiants
pubmed: 39443369
doi: 10.1007/s00203-024-04175-1
pii: 10.1007/s00203-024-04175-1
doi:
Substances chimiques
Quercetin
9IKM0I5T1E
Anti-Bacterial Agents
0
beta-Cyclodextrins
0
Hydrogen Peroxide
BBX060AN9V
Photosensitizing Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
445Subventions
Organisme : 2023 Guangxi University for Nationalities Graduate Education Innovation Plan Project
ID : gxun chxs2024110
Organisme : Science and Technology Major Project of Guangxi
ID : Guike AB21196020
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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