Histopathologic findings of the lens capsule and persistent hyperplastic primary vitreous in Korean pediatric cataract patients.
Lens capsule
Pathology
Pediatric cataract
Persistent hyperplastic primary vitreous
Retrolental membrane
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 10 2024
23 10 2024
Historique:
received:
16
06
2024
accepted:
09
10
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
24
10
2024
Statut:
epublish
Résumé
This study aimed to measure lens capsule thickness and investigate histopathologic characteristics of persistent hyperplastic primary vitreous (PHPV) in Korean pediatric cataracts. We analyzed lens capsules from 116 eyes of 83 pediatric cataract patients treated between 2011 and 2015. The mean thickness of the anterior/posterior capsule was 7.21 ± 1.74/4.39 ± 1.41 μm. PHPV was observed in 11.2% (13/116) of eyes. Histologic examination revealed that PHPV is typically characterized by retrolenticular membranes with hypercellular membrane tissue comprising vascular structures and/or mesenchymal cells, seen in 69% of cases. Only 3 patients had hyaloid arteries and endothelium-lined blood vessels in the retrolenticular membranes, whereas six eyes showed only mesenchymal cells. Lens capsule thickness did not significantly vary with age or the presence of PHPV in Korean pediatric cataracts. The primary histological characteristic of PHPV was the presence of mesenchymal cells, with or without vascular structures, supporting the role of endothelial-mesenchymal transition as a key mechanism in vascular regression.
Identifiants
pubmed: 39443626
doi: 10.1038/s41598-024-76000-0
pii: 10.1038/s41598-024-76000-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25105Subventions
Organisme : Inje University
ID : 20150684
Informations de copyright
© 2024. The Author(s).
Références
Sheeladevi, S., Lawrenson, J. G., Fielder, A. R. & Suttle, C. M. Global prevalence of childhood cataract: A systematic review. Eye (London)30, 1160–1169 (2016).
doi: 10.1038/eye.2016.156
pubmed: 27518543
Tariq, M. A. et al. Prevalence of Pediatric cataract in asia: A systematic review and meta-analysis. J. Curr. Ophthalmol.34, 148–159 (2022).
doi: 10.4103/joco.joco_339_21
pubmed: 36147271
pmcid: 9487007
Reese, A. B. Persistent hyperplastic primary vitreous. Am. J. Ophthalmol.40, 317–331 (1955).
doi: 10.1016/0002-9394(55)91866-3
pubmed: 13248898
Kaste, S. C., Jenkins, J. J. 3., Meyer, D., Fontanesi, J. & Pratt, C. B. Persistent hyperplastic primary vitreous of the eye: Imaging findings with pathologic correlation. AJR Am. J. Roentgenol.162, 437–440 (1994).
doi: 10.2214/ajr.162.2.8310942
pubmed: 8310942
Shastry, B. S. Persistent hyperplastic primary vitreous: Congenital malformation of the eye. Clin. Exp. Ophthalmol.37, 884–890 (2009).
doi: 10.1111/j.1442-9071.2009.02150.x
pubmed: 20092598
Kim, J. H., Kim, J. H., Yu, Y. S., Mun, J. Y. & Kim, K. W. Autophagy-induced regression of hyaloid vessels in early ocular development. Autophagy6, 922–928 (2010).
doi: 10.4161/auto.6.7.13306
pubmed: 20818164
Reichel, M. B. et al. High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice. Cell. Death Differ.5, 156–162 (1998).
doi: 10.1038/sj.cdd.4400326
pubmed: 10200460
Thomas, D. M., Kannabiran, C. & Balasubramanian, D. Identification of key genes and pathways in persistent hyperplastic primary vitreous of the eye using bioinformatic analysis. Front. Med. (Lausanne)8, 690594 (2021).
doi: 10.3389/fmed.2021.690594
pubmed: 34485332
Goldberg, M. F. Persistent fetal vasculature (PFV): An integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV). LIV Edward Jackson Memorial lecture. Am. J. Ophthalmol.124, 587–626 (1997).
doi: 10.1016/S0002-9394(14)70899-2
pubmed: 9372715
Klein, M. Investigation concerning the lens capsule: Its importance in the technique of intra-capsular cataract extraction. Br. J. Ophthalmol.26, 118–126 (1942).
doi: 10.1136/bjo.26.3.118
pubmed: 18169826
pmcid: 1143381
Barraquer, R. I., Michael, R., Abreu, R., Lamarca, J. & Tresserra, F. Human lens capsule thickness as a function of age and location along the sagittal lens perimeter. Invest. Ophthalmol. Vis. Sci.47, 2053–2060 (2006).
doi: 10.1167/iovs.05-1002
pubmed: 16639015
Pollard, Z. F. Persistent hyperplastic primary vitreous: Diagnosis, treatment and results. Trans. Am. Ophthalmol. Soc.95, 487–549 (1997).
pubmed: 9440186
pmcid: 1298374
Li, A. et al. Endothelial-to-mesenchymal transition: A potential mechanism for atherosclerosis plaque progression and destabilization. DNA Cell. Biol.36, 883–891 (2017).
doi: 10.1089/dna.2017.3779
pubmed: 28920704
Shu, D. Y., Butcher, E. & Saint-Geniez, M. EMT and EndMT: Emerging roles in age-related macular degeneration. Int. J. Mol. Sci.21 (2020).
Haddad, R., Font, R. L. & Reeser, F. Persistent hyperplastic primary vitreous. A clinicopathologic study of 62 cases and review of the literature. Surv. Ophthalmol.23, 123–134 (1978).
doi: 10.1016/0039-6257(78)90091-7
pubmed: 100893
Galhotra, R., Gupta, K., Kaur, S. & Singh, P. Bilateral persistent hyperplastic primary vitreous: A rare entity. Oman J. Ophthalmol.5, 58–60 (2012).
doi: 10.4103/0974-620X.94780
pubmed: 22557881
pmcid: 3339679
Sanghvi, D. A., Sanghvi, C. A. & Purandare, N. C. Bilateral persistent hyperplastic primary vitreous. Australas Radiol.49, 72–74 (2005).
doi: 10.1111/j.1440-1673.2005.01402.x
pubmed: 15727615
Jain, T. P. Bilateral persistent hyperplastic primary vitreous. Indian J. Ophthalmol.57, 53–54 (2009).
doi: 10.4103/0301-4738.44487
pubmed: 19075412
pmcid: 2661510
Hunt, A., Rowe, N., Lam, A. & Martin, F. Outcomes in persistent hyperplastic primary vitreous. Br. J. Ophthalmol.89, 859–863 (2005).
doi: 10.1136/bjo.2004.053595
pubmed: 15965167
pmcid: 1772745
Li, L. et al. Surgical treatment and visual outcomes of cataract with persistent hyperplastic primary vitreous. Int. J. Ophthalmol.10, 391–399 (2017).
pubmed: 28393030
pmcid: 5360774
Khandwala, N., Besirli, C. & Bohnsack, B. L. Outcomes and surgical management of persistent fetal vasculature. BMJ Open. Ophthalmol.6, e000656 (2021).
doi: 10.1136/bmjophth-2020-000656
pubmed: 34013048
pmcid: 8094357
Cernea, P., Simionescu, C. & Bosun, I. Persistence of the primordial vitreous body and buphthalmos. Oftalmologia39, 338–342 (1995).
pubmed: 7577904
Hara, S. et al. Immunoreactive opsin and glial fibrillary acidic protein in persistent hyperplastic primary vitreous. Acta Ophthalmol. (Copenh)66, 413–418 (1988).
doi: 10.1111/j.1755-3768.1988.tb04033.x
pubmed: 2973723
Spitznas, M., Koch, F. & Pohl, S. Ultrastructural pathology of anterior persistent hyperplastic primary vitreous. Graefes Arch. Clin. Exp. Ophthalmol.228, 487–496 (1990).
doi: 10.1007/BF00927267
pubmed: 2227497
Lambert, S. R., Buckley, E. G., Lenhart, P. D., Zhang, Q. & Grossniklaus, H. E. Congenital fibrovascular pupillary membranes: Clinical and histopathologic findings. Ophthalmology119, 634–641 (2012).
doi: 10.1016/j.ophtha.2011.08.043
pubmed: 22197437
Li, L., Lu, H., Li, B., Li, L. Q. & Gao, F. Histopathological study of retrolental membranes secondary to persistent hyperplastic primary vitreous. Zhonghua Yan Ke Za Zhi46, 317–322 (2010).
pubmed: 20654058