Active CNS delivery of oxycodone in healthy and endotoxemic pigs.
Blood-cerebrospinal fluid barrier
Blood–brain barrier
Brain interstitial fluid
Cerebrospinal fluid
Endotoxemia
Lipopolysaccharide
Microdialysis
Oxycodone
Porcine
Proton-coupled organic cation antiporter
Journal
Fluids and barriers of the CNS
ISSN: 2045-8118
Titre abrégé: Fluids Barriers CNS
Pays: England
ID NLM: 101553157
Informations de publication
Date de publication:
23 Oct 2024
23 Oct 2024
Historique:
received:
26
08
2024
accepted:
04
10
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
24
10
2024
Statut:
epublish
Résumé
The primary objective of this study was to advance our understanding of active drug uptake at brain barriers in higher species than rodents, by examining oxycodone brain concentrations in pigs. This was investigated by a microdialysis study in healthy and endotoxemic conditions to increase the understanding of inter-species translation of putative proton-coupled organic cation (H Our findings provide novel evidence of higher unbound oxycodone concentrations in brain ISF compared to blood, yielding an unbound brain-to-plasma concentration ratio (K This study enhances our understanding of oxycodone pharmacokinetics and CNS drug delivery in both healthy and inflamed conditions, providing crucial insights for translating these findings to clinical settings.
Sections du résumé
BACKGROUND
BACKGROUND
The primary objective of this study was to advance our understanding of active drug uptake at brain barriers in higher species than rodents, by examining oxycodone brain concentrations in pigs.
METHODS
METHODS
This was investigated by a microdialysis study in healthy and endotoxemic conditions to increase the understanding of inter-species translation of putative proton-coupled organic cation (H
RESULTS
RESULTS
Our findings provide novel evidence of higher unbound oxycodone concentrations in brain ISF compared to blood, yielding an unbound brain-to-plasma concentration ratio (K
CONCLUSIONS
CONCLUSIONS
This study enhances our understanding of oxycodone pharmacokinetics and CNS drug delivery in both healthy and inflamed conditions, providing crucial insights for translating these findings to clinical settings.
Identifiants
pubmed: 39443944
doi: 10.1186/s12987-024-00583-z
pii: 10.1186/s12987-024-00583-z
doi:
Substances chimiques
Oxycodone
CD35PMG570
Analgesics, Opioid
0
Lipopolysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
86Subventions
Organisme : Innovative Medicines Initiative
ID : 807015, 2019
Organisme : Vetenskapsrådet
ID : 2018-03310, 2018
Informations de copyright
© 2024. The Author(s).
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