Bilateral lumbar pedicle fracture in a patient receiving long-term bisphosphonate therapy: a case report with pathological evaluation.

Humans Female Lumbar Vertebrae / diagnostic imaging Diphosphonates / adverse effects Spinal Fractures / chemically induced Aged, 80 and over Bone Density Conservation Agents / adverse effects Osteoporosis / drug therapy Spinal Fusion / adverse effects Magnetic Resonance Imaging Tomography, X-Ray Computed
Atypical fracture Bilateral pedicle fracture Bisphosphonate Low bone turnover Osteoporosis

Journal

Archives of osteoporosis
ISSN: 1862-3514
Titre abrégé: Arch Osteoporos
Pays: England
ID NLM: 101318988

Informations de publication

Date de publication:
24 Oct 2024
Historique:
received: 11 06 2024
accepted: 17 10 2024
medline: 24 10 2024
pubmed: 24 10 2024
entrez: 24 10 2024
Statut: epublish

Résumé

Bilateral pedicle fractures of the lumbar spine are uncommon and are typically associated with strenuous activities, traumatic events, or previous spinal surgery. This study reported a case of bilateral pedicle fracture in a patient with a long history of osteoporosis treatment with bisphosphonate and included a histological evaluation of the bone. An 82-year-old woman with no history of trauma presented to our hospital with back pain that had worsened over the previous month. Computed tomography and magnetic resonance imaging revealed bilateral pedicle fractures of the third lumbar vertebra. She had osteoporosis and had been taking bisphosphonates for 9 years. The patient underwent posterior lumbar fusion, and her symptoms improved. Bone biopsy results from the spinous process revealed few osteoblasts and an absence of osteoclasts, indicating low bone turnover. Long-term use of bisphosphonates may contribute to the development of atypical bilateral pedicle fractures in patients with osteoporosis.

Sections du résumé

BACKGROUND BACKGROUND
Bilateral pedicle fractures of the lumbar spine are uncommon and are typically associated with strenuous activities, traumatic events, or previous spinal surgery. This study reported a case of bilateral pedicle fracture in a patient with a long history of osteoporosis treatment with bisphosphonate and included a histological evaluation of the bone.
CASE PRESENTATION METHODS
An 82-year-old woman with no history of trauma presented to our hospital with back pain that had worsened over the previous month. Computed tomography and magnetic resonance imaging revealed bilateral pedicle fractures of the third lumbar vertebra. She had osteoporosis and had been taking bisphosphonates for 9 years. The patient underwent posterior lumbar fusion, and her symptoms improved. Bone biopsy results from the spinous process revealed few osteoblasts and an absence of osteoclasts, indicating low bone turnover.
CONCLUSIONS CONCLUSIONS
Long-term use of bisphosphonates may contribute to the development of atypical bilateral pedicle fractures in patients with osteoporosis.

Identifiants

DOI: 10.1007/s11657-024-01462-8 PMID: 39446247
pubmed: 39446247
doi: 10.1007/s11657-024-01462-8
pii: 10.1007/s11657-024-01462-8
doi:

Substances chimiques

Diphosphonates 0
Bone Density Conservation Agents 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103

Informations de copyright

© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.

Références

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Auteurs

Ryo Fujita (R)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan. chm-l-mln-ryo1111@hotmail.co.jp.
Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. chm-l-mln-ryo1111@hotmail.co.jp.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan. chm-l-mln-ryo1111@hotmail.co.jp.

Kota Suda (K)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Zen-Ichi Tanei (ZI)

Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Satoko Matsumoto Harmon (SM)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Miki Komatsu (M)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Keiichi Nakai (K)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Kento Inomata (K)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Shin Matsushima (S)

Hokkaido Spinal Cord Injury Center, Higashi-4, Minami-1, 3-1, Bibai, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Tsutomu Endo (T)

Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Katsuhisa Yamada (K)

Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Masahiko Takahata (M)

Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

Norimasa Iwasaki (N)

Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Department of Orthopedic Surgery, Dokkyo Medical University, Tochigi, Japan.

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questionsmedicales.fr › Appareil locomoteur › Squelette › Rachis › Vertèbres lombales › Bilateral lumbar pedicle fracture in a patient...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Bilateral lumbar pedicle fracture in a patient...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Fractures du rachis › Bilateral lumbar pedicle fracture in a patient...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Bilateral lumbar pedicle fracture in a patient...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents de maintien de la densité osseuse › Bilateral lumbar pedicle fracture in a patient...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Bilateral lumbar pedicle fracture in a patient...
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questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Bilateral lumbar pedicle fracture in a patient...