The effects of topical latanoprost 0.005% treatment on microvascular changes in the optic nerve head and macula.
Humans
Latanoprost
/ administration & dosage
Prospective Studies
Optic Disk
/ blood supply
Female
Male
Tomography, Optical Coherence
/ methods
Glaucoma, Open-Angle
/ drug therapy
Macula Lutea
/ blood supply
Middle Aged
Intraocular Pressure
/ drug effects
Antihypertensive Agents
/ administration & dosage
Fluorescein Angiography
/ methods
Retinal Vessels
/ drug effects
Follow-Up Studies
Ophthalmic Solutions
/ administration & dosage
Administration, Topical
Microvessels
/ drug effects
Fundus Oculi
Aged
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
01 Nov 2024
01 Nov 2024
Historique:
received:
17
03
2024
accepted:
12
08
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
ppublish
Résumé
This prospective study aimed to assess the impact of topical latanoprost 0.005% treatment on the microvasculature of the macula and optic nerve head (ONH) in primary open-angle glaucoma (POAG). Fifty-seven eyes of 31 subjects were enrolled. ONH whole-image (wiVD), peripapillary (ppVD), and macular vascular density (VD) parameters were measured using optical coherence tomography angiography before treatment, at the 1st month, and at the 3rd month of treatment. There was a significant reduction in IOP post treatment, with a decrease of 17.0 ± 2.3 mmHg in the 1st month and 16.3 ± 2.5 mmHg in the 3rd month (P < 0.001 for both). ONH wiVD and ppVD significantly increased at the post-treatment 1st month (P = 0.001 for both) but decreased by the 3rd month, returning to baseline levels (P < 0.001 for both), indicating a return to pre-treatment levels (P > 0.05 for both). Similarly, macular wiVD and perifoveolar VD (pefVD) increased significantly at the 1st month (P = 0.013 and P < 0.001, respectively) but returned to baseline by the 3rd month (P < 0.001 for both). No significant difference was observed between before-treatment and post-treatment 3rd month regarding the macular wiVD and pefVD (P > 0.05 for both). Deep capillary plexus and foveal avascular zone parameters did not change during follow-up (P > 0.05 for both). The initial increase in ONH and peripapillary VD, as well as macular VD, is attributed to the acute reduction in IOP from topical latanoprost 0.005%. However, the diminishment of sustained differences by the 3rd month indicates adaptation of the ONH and retinal microvasculature to decreased IOP through compensatory mechanisms.
Identifiants
pubmed: 39449534
doi: 10.4103/IJO.IJO_648_24
pii: 02223307-202411005-00030
doi:
Substances chimiques
Latanoprost
6Z5B6HVF6O
Antihypertensive Agents
0
Ophthalmic Solutions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S907-S912Informations de copyright
Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.
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