Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells.

Imidazoles / pharmacology Humans Tumor Suppressor Protein p53 / metabolism Apoptosis / drug effects Melanoma / drug therapy Piperazines / pharmacology Cell Line, Tumor Cell Survival / drug effects Proto-Oncogene Proteins c-mdm2 / metabolism Antineoplastic Agents / pharmacology
MDM2 inhibitors Notch-1 cell cycle ethosomes melanoma nanodelivery nutlin-3a p53

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
11 Oct 2024
Historique:
received: 06 09 2024
revised: 04 10 2024
accepted: 09 10 2024
medline: 25 10 2024
pubmed: 25 10 2024
entrez: 25 10 2024
Statut: epublish

Résumé

This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility, limiting its bio-distribution and therapeutic efficacy. The potential of nutlin-3a-loaded ethosomes was investigated on two in vitro models of melanoma: the HT144 cell line p53

Identifiants

DOI: 10.3390/cells13201678 PMID: 39451196
pubmed: 39451196
pii: cells13201678
doi: 10.3390/cells13201678
pii:
doi:

Substances chimiques

nutlin 3 53IA0V845C
Imidazoles 0
Tumor Suppressor Protein p53 0
Piperazines 0
Proto-Oncogene Proteins c-mdm2 EC 2.3.2.27
Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Arianna Romani (A)

Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
ORCID: 0000-0001-8000-6178

Giada Lodi (G)

Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.

Fabio Casciano (F)

Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
ORCID: 0000-0002-6431-3335

Arianna Gonelli (A)

Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.

Paola Secchiero (P)

Department of Translational Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.

Giorgio Zauli (G)

Research Department, King Khaled Eye Specialistic Hospital, Riyadh 12329-8139, Saudi Arabia.

Olga Bortolini (O)

Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
ORCID: 0000-0002-8428-2310

Giuseppe Valacchi (G)

Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
Plants for Human Health Institute, Animal Sciences Department, NC Research Campus, NC State University, Kannapolis, NC 28081, USA.
Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea.
ORCID: 0000-0002-8792-0947

Daniele Ragno (D)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
ORCID: 0000-0003-0016-290X

Agnese Bondi (A)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.

Mascia Benedusi (M)

Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.

Elisabetta Esposito (E)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
ORCID: 0000-0002-8416-3629

Rebecca Voltan (R)

Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
ORCID: 0000-0002-6747-3465

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines proto-oncogènes c-mdm2 › Enhanced Anti-Melanoma Activity of Nutlin-3a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Enhanced Anti-Melanoma Activity of Nutlin-3a...