The Role of Tumor Biomarkers in Tailoring the Approach to Advanced Ovarian Cancer.

Humans Female Biomarkers, Tumor / genetics Ovarian Neoplasms / genetics BRCA1 Protein / genetics Mutation BRCA2 Protein / genetics Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use Carcinoma, Ovarian Epithelial / genetics Precision Medicine / methods
BRCA HRD Parpi gynecologic oncology molecular classification ovarian cancer target therapies

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Oct 2024
Historique:
received: 21 09 2024
revised: 11 10 2024
accepted: 16 10 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

Growing evidence has demonstrated the role of mutations of tumor biomarkers in diagnosing and treating epithelial ovarian cancer. This review aims to analyze recent literature on the correlation between tumor biomarkers and chemotherapy in nonmucinous ovarian cancer, providing suggestions for personalized treatment approaches. An extensive literature search was conducted to identify relevant studies and trials.

Identifiants

DOI: 10.3390/ijms252011239 PMID: 39457020
pubmed: 39457020
pii: ijms252011239
doi: 10.3390/ijms252011239
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
BRCA1 Protein 0
BRCA2 Protein 0
Poly(ADP-ribose) Polymerase Inhibitors 0
BRCA1 protein, human 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Noemi Tonti (N)

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
ORCID: 0009-0006-3503-5010

Tullio Golia D'Augè (T)

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
ORCID: 0000-0002-1018-3088

Ilaria Cuccu (I)

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.

Emanuele De Angelis (E)

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
ORCID: 0009-0009-9930-2810

Ottavia D'Oria (O)

Obstetrics and Gynecological Unit, Department of Woman's and Child's Health, San Camillo-Forlanini Hospital, 00152 Rome, Italy.

Giorgia Perniola (G)

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
ORCID: 0000-0003-0321-9828

Antonio Simone Laganà (AS)

Unit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0003-1543-2802

Andrea Etrusco (A)

Unit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0001-7414-4224

Federico Ferrari (F)

Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
ORCID: 0000-0001-7065-2432

Stefania Saponara (S)

Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.
ORCID: 0000-0003-1022-0958

Violante Di Donato (V)

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
ORCID: 0000-0002-9254-5790

Giorgio Bogani (G)

Gynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

Andrea Giannini (A)

Unit of Gynecology, Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
ORCID: 0000-0002-4388-0082

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine BRCA1 › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéine BRCA2 › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de poly(ADP-ribose) polymérases › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Carcinome épithélial de l'ovaire › The Role of Tumor Biomarkers in Tailoring the...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › The Role of Tumor Biomarkers in Tailoring the...