6-Gingerol Inhibits De Novo Lipogenesis by Targeting Stearoyl-CoA Desaturase to Alleviate Fructose-Induced Hepatic Steatosis.
Animals
Fatty Alcohols
/ pharmacology
Stearoyl-CoA Desaturase
/ metabolism
Lipogenesis
/ drug effects
Fructose
/ metabolism
Rats
Humans
Male
Catechols
/ pharmacology
Mice
Molecular Docking Simulation
Hep G2 Cells
Non-alcoholic Fatty Liver Disease
/ metabolism
Rats, Sprague-Dawley
Triglycerides
/ metabolism
Fatty Liver
/ metabolism
Liver
/ metabolism
Mice, Inbred C57BL
6-gingerol
hepatic steatosis
metabolic-associated fatty liver disease
stearoyl-CoA desaturase
target
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Oct 2024
20 Oct 2024
Historique:
received:
26
09
2024
revised:
18
10
2024
accepted:
18
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
epublish
Résumé
Metabolic-associated fatty liver disease (MAFLD), also known as non-alcoholic fatty liver disease (NAFLD), is a worldwide liver disease without definitive or widely used therapeutic drugs in clinical practice. In this study, we confirm that 6-gingerol (6-G), an active ingredient of ginger (
Identifiants
pubmed: 39457074
pii: ijms252011289
doi: 10.3390/ijms252011289
pii:
doi:
Substances chimiques
Fatty Alcohols
0
Stearoyl-CoA Desaturase
EC 1.14.19.1
Fructose
30237-26-4
gingerol
925QK2Z900
Catechols
0
Triglycerides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82104469
Organisme : Natural Science Foundation of Chongqing
ID : cstc2021jcyj-bshX0161
Organisme : Scientific and Technological Research Program of Chongqing Municipal Education Commission
ID : KJQN202100417
Organisme : National Natural Science Foundation of China
ID : 82274164