Cannabis Use and Cannabidiol Modulate HIV-Induced Alterations in TREM2 Expression: Implications for Age-Related Neuropathogenesis.

Receptors, Immunologic / metabolism Animals Membrane Glycoproteins / metabolism Mice Cannabidiol / pharmacology Humans HIV Infections / drug therapy Male Macrophages / metabolism Female Cannabis
CBD HIV TREM2 cannabis immunomodulatory neuroinflammation

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
24 Sep 2024
Historique:
received: 02 08 2024
revised: 04 09 2024
accepted: 18 09 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

Triggering receptor expressed on myeloid cells 2 (TREM2) is involved in neuroinflammation and HIV-associated neurocognitive impairment (NCI). People with HIV (PWH) using cannabis exhibit lower inflammation and neurological disorders. We hypothesized that TREM2 dysfunction mediates HIV neuropathogenesis and can be reversed by cannabinoids. EcoHIV-infected wildtype (WT) and TREM2

Identifiants

DOI: 10.3390/v16101509 PMID: 39459844
pubmed: 39459844
pii: v16101509
doi: 10.3390/v16101509
pii:
doi:

Substances chimiques

Receptors, Immunologic 0
Membrane Glycoproteins 0
Cannabidiol 19GBJ60SN5
TREM2 protein, human 0
Trem2 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Bryant Avalos (B)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0000-0002-1863-2060

Jacqueline R Kulbe (JR)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

Mary K Ford (MK)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

Anna Elizabeth Laird (AE)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

Kyle Walter (K)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0009-0004-0323-8222

Michael Mante (M)

Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, 9880 Mesa Rim Road, San Diego, CA 92121, USA.

Jazmin B Florio (JB)

Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, 9880 Mesa Rim Road, San Diego, CA 92121, USA.

Ali Boustani (A)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0000-0001-8146-7574

Antoine Chaillon (A)

Department of Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0000-0001-9490-3857

Johannes C M Schlachetzki (JCM)

Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0000-0002-7801-9743

Erin E Sundermann (EE)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0000-0001-5821-8035

David J Volsky (DJ)

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Robert A Rissman (RA)

Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, 9880 Mesa Rim Road, San Diego, CA 92121, USA.

Ronald J Ellis (RJ)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
ORCID: 0000-0003-4931-752X

Scott L Letendre (SL)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Department of Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

Jennifer Iudicello (J)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

Jerel Adam Fields (JA)

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Cannabidiol › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Cannabis Use and Cannabidiol Modulate...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Cannabaceae › Cannabis › Cannabis Use and Cannabidiol Modulate...