Humans Leukemia, Myeloid, Acute / genetics Male Adolescent Receptors, Cytokine / genetics Antigens, CD19 / immunology Female Gene Rearrangement Cell Lineage Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics Molecular Targeted Therapy
Chimeric antigen receptor - CAR Immunotherapy Leukemia Next generation sequencing - NGS

Journal

Journal for immunotherapy of cancer
ISSN: 2051-1426
Titre abrégé: J Immunother Cancer
Pays: England
ID NLM: 101620585

Informations de publication

Date de publication:
26 Oct 2024
Historique:
accepted: 08 09 2024
medline: 27 10 2024
pubmed: 27 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

Lineage switch (LS) refers to the immunophenotypic transformation of one leukemia lineage to another (ie, lymphoid to myeloid) with retention of baseline genetics. This phenomenon was originally observed in infants with B-lymphoblastic leukemia (B-ALL) with

Identifiants

DOI: 10.1136/jitc-2024-009499 PMID: 39461880
pubmed: 39461880
pii: jitc-2024-009499
doi: 10.1136/jitc-2024-009499
pii:
doi:

Substances chimiques

CRLF2 protein, human 0
Receptors, Cytokine 0
Antigens, CD19 0
CD19 molecule, human 0

Types de publication

Journal Article Case Reports

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: NS receives research funding from Lentigen, VOR Bio and CARGO therapeutics and has participated in Advisory Boards for Sobi, Allogene, invoX, ImmunoACT, and VOR. KL is a Clinical Scholar of the Leukemia & Lymphoma Society. KL has participated in advisory boards and consulting for Jazz Pharmaceuticals. IK is a full time employee of Adaptive Biotechnologies. BLW has consulting agreements with Amgen and Kite for MRD clinical trial advising.

Auteurs

Sara K Silbert (SK)

National Cancer Institute Pediatric Oncology Branch, Bethesda, Maryland, USA.

Samantha Scanlon (S)

Department of Pediatric Hematology & Oncology, University of Washington, Seattle, Washington, USA.

Hao-Wei Wang (HW)

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.

Constance M Yuan (CM)

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.

Alyssa Doverte (A)

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.

Jake Wellek (J)

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.

Nisha Patel (N)

Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.

Raul Braylan (R)

Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.

Mark Ahlman (M)

Department of Radiology and Imaging, Medical College of Georgia, Augusta, Georgia, USA.

Evrim B Turkbey (EB)

Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.

Sandra D Bohling (SD)

Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA.
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.

Karen M Chisholm (KM)

Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA.
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.

Murat Alp Oztek (MA)

Department of Radiology, University of Washington, Seattle, Washington, USA.

Mike LaLoggia (M)

Lake Erie College of Osteopathic Medicine, Rochester, New York, USA.

Anupam Verma (A)

National Cancer Institute Pediatric Oncology Branch, Bethesda, Maryland, USA.
Pediatric Hematology/Oncology, Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
Center for Cancer and Blood Disorders, Children's National Hospital, Washington, District of Columbia, USA.

Haneen Shalabi (H)

National Cancer Institute Pediatric Oncology Branch, Bethesda, Maryland, USA.

Alexandra E Kovach (AE)

Hematopathology, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Clinical Pathology, USC Keck School of Medicine, Los Angeles, California, USA.

Brent L Wood (BL)

Hematopathology, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Pathology, USC Keck School of Medicine, Los Angeles, California, USA.

Adam Lamble (A)

Department of Pediatric Hematology & Oncology, University of Washington, Seattle, Washington, USA.

Ilan Kirsch (I)

Adaptive Biotechnologies, Seattle, Washington, USA.

Kasey Leger (K)

Department of Pediatric Hematology & Oncology, University of Washington, Seattle, Washington, USA nirali.shah@nih.gov Kasey.Leger@seattlechildrens.org.

Nirali N Shah (NN)

National Cancer Institute Pediatric Oncology Branch, Bethesda, Maryland, USA nirali.shah@nih.gov Kasey.Leger@seattlechildrens.org.
ORCID: 0000-0002-8474-9080

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde ›
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines ›
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes B › Antigènes CD19 ›
questionsmedicales.fr › Phénomènes génétiques › Réarrangement des gènes ›
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire ›
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs B ›
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée ›