Association of FTO variants rs9939609 and rs1421085 with elevated sugar and fat consumption in adult obesity.
Dietary intake
FTO gene
Genetic risk
Human genetics
Obesity
Single nucleotide polymorphisms
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 10 2024
27 10 2024
Historique:
received:
10
06
2024
accepted:
18
10
2024
medline:
28
10
2024
pubmed:
28
10
2024
entrez:
28
10
2024
Statut:
epublish
Résumé
This cross-sectional study explores the impact of FTO gene single nucleotide polymorphisms (SNPs) rs9939609 and rs1421085 on dietary habits contributing to obesity risk in Thai adults. The study enrolled 384 participants from Bangkok, categorized as non-obese (BMI < 25 kg/m
Identifiants
pubmed: 39463443
doi: 10.1038/s41598-024-77004-6
pii: 10.1038/s41598-024-77004-6
doi:
Substances chimiques
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
EC 1.14.11.33
FTO protein, human
EC 1.14.11.33
Dietary Fats
0
Leptin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25618Informations de copyright
© 2024. The Author(s).
Références
Lin, X. & Li, H. Obesity: Epidemiology, pathophysiology, and therapeutics. Front Endocrinol. (Lausanne) 12, 706978 (2021).
pubmed: 34552557
doi: 10.3389/fendo.2021.706978
Sakboonyarat, B. et al. Rising trends in obesity prevalence among Royal Thai Army personnel from 2017 to 2021. Sci. Rep. 12, 7726 (2022).
pubmed: 35546180
pmcid: 9095636
doi: 10.1038/s41598-022-11913-2
Hruby, A. & Hu, F. B. The epidemiology of obesity: A big picture. Pharmacoeconomics 33, 673–689 (2015).
pubmed: 25471927
pmcid: 4859313
doi: 10.1007/s40273-014-0243-x
Hill, J. O. et al. Energy balance and obesity. Circulation 126, 126–132 (2012).
pubmed: 22753534
pmcid: 3401553
doi: 10.1161/CIRCULATIONAHA.111.087213
Albuquerque, D. et al. The contribution of genetics and environment to obesity. Br. Med. Bull. 123, 159–173 (2017).
pubmed: 28910990
doi: 10.1093/bmb/ldx022
Popović, A. M. et al. FTO gene polymorphisms at the crossroads of metabolic pathways of obesity and epigenetic influences. Food Technol. Biotechnol. 61, 14–26 (2023).
pubmed: 37200795
pmcid: 10187569
doi: 10.17113/ftb.61.01.23.7594
Inandiklioğlu, N. & Yaşar, A. Association between rs1421085 and rs9939609 polymorphisms of fat mass and obesity-associated gene with high-density lipoprotein cholesterol and triglyceride in obese Turkish children and adolescents. J. Pediatr. Genet. 10, 9–15 (2021).
pubmed: 33552632
doi: 10.1055/s-0040-1713154
Ağagündüz, D. & Gezmen-Karadağ, M. Association of FTO common variant (rs9939609) with body fat in Turkish individuals. Lipids Health Dis. 18, 212 (2019).
pubmed: 31810473
pmcid: 6896279
doi: 10.1186/s12944-019-1160-y
Song, Y. et al. Polymorphisms of fat mass and obesity-associated gene in the pathogenesis of child and adolescent metabolic syndrome. Nutrients 15, 2643 (2023).
pubmed: 37375547
pmcid: 10302564
doi: 10.3390/nu15122643
Chuenta, W. et al. Common variations in the FTO gene and obesity in Thais: A family-based study. Gene 558, 75–81 (2015).
pubmed: 25542809
doi: 10.1016/j.gene.2014.12.050
Rahimlou, M. et al. Fat mass and obesity-associated gene (FTO) rs9939609 (A/T) polymorphism and food preference in obese people with low-calorie intake and non-obese individuals with high-calorie intake. BMC Nutr. 9, 143 (2023).
pubmed: 38057923
pmcid: 10698998
doi: 10.1186/s40795-023-00804-y
Chuang, Y. F. et al. FTO genotype and aging: Pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet. Mol. Psychiatry 20, 133–139 (2015).
pubmed: 24863145
doi: 10.1038/mp.2014.49
Saber-Ayad, M. et al. The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population. PLoS One 14, e0223808 (2019).
pubmed: 31622411
pmcid: 6797190
doi: 10.1371/journal.pone.0223808
Harbron, J. et al. Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese Caucasian adults. Nutrients 6, 3130–3152 (2014).
pubmed: 25102252
pmcid: 4145299
doi: 10.3390/nu6083130
Melhorn, S. et al. FTO genotype impacts food intake and corticolimbic activation. Am. J. Clin. Nutr. 107, 145–154 (2018).
pubmed: 29529147
pmcid: 6454473
doi: 10.1093/ajcn/nqx029
Al-Jawadi, A. A. et al. Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults. BMC Res. Notes 14, 411 (2021).
pubmed: 34743743
pmcid: 8574008
doi: 10.1186/s13104-021-05823-1
Rana, S. & Bhatti, A. A. Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals. Eat. Weight Disord. 25, 1321–1332 (2020).
pubmed: 31468339
doi: 10.1007/s40519-019-00765-x
Laber, S. et al. Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo. Sci Adv 7, eabg0108 (2021).
pubmed: 34290091
pmcid: 8294759
doi: 10.1126/sciadv.abg0108
Qi, Q. et al. FTO genetic variants, dietary intake and body mass index: Insights from 177,330 individuals. Hum. Mol. Genet. 23, 6961–6972 (2014).
pubmed: 25104851
pmcid: 4271061
doi: 10.1093/hmg/ddu411
Young, A. I. et al. Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index. Nat. Commun. 7, 12724 (2016).
pubmed: 27596730
pmcid: 5025863
doi: 10.1038/ncomms12724
Chiang, K.-M. et al. Genome-wide association study of morbid obesity in Han Chinese. BMC Genet. 20, 97 (2019).
pubmed: 31852448
pmcid: 6921553
doi: 10.1186/s12863-019-0797-x
Daya, M. et al. Obesity risk and preference for high dietary fat intake are determined by FTO rs9939609 gene polymorphism in selected Indonesian adults. Asia Pac. J. Clin. Nutr. 28, 183–191 (2019).
pubmed: 30896430
Boonyuen, U. et al. Glucose-6-phosphate dehydrogenase mutations in malaria endemic area of Thailand by multiplexed high-resolution melting curve analysis. Malar. J. 20, 194 (2021).
pubmed: 33879156
pmcid: 8056697
doi: 10.1186/s12936-021-03731-0
Katayutanon, T. et al. Factors relating to physical activities of the elderly in a Village, Bangpla Subdistrict, Bangplee District, Samutprakarn Province. HCU J. 23, 1–14 (2019).
Adıgüzel, İ et al. Adaptation of the global physical activity questionnaire (GPAQ) into Turkish: A validation and reliability study. Turk. J. Phys. Med. Rehabil. 67, 175–186 (2021).
pubmed: 34396068
pmcid: 8343159
doi: 10.5606/tftrd.2021.1675
Sama, S. et al. Quantifying the homeostatic model assessment of insulin resistance to predict mortality in multi-organ dysfunction syndrome. Indian J. Crit. Care Med. 25, 1364–1369 (2021).
pubmed: 35027795
pmcid: 8693111
doi: 10.5005/jp-journals-10071-24043
Ghosh, S. & Collier, A. Diagnosis, classification, epidemiology and biochemistry. In Churchill’s pocketbook of diabetes (eds Ghosh, S. & Collier, A.) 1–49 (Churchill Livingstone, 2012).
Nirdnoy, N. et al. Validation of a Thai semiquantitative food frequency questionnaire (semi-FFQ) for people at risk of metabolic syndrome. J. Health Popul. Nutr. 42, 13 (2023).
pubmed: 36814306
pmcid: 9948462
doi: 10.1186/s41043-023-00353-x
Witek, K. et al. A high-sugar diet consumption, metabolism and health impacts with a focus on the development of substance use disorder: A narrative review. Nutrients 14, 2940 (2022).
pubmed: 35889898
pmcid: 9323357
doi: 10.3390/nu14142940
Liu, A. G. et al. A healthy approach to dietary fats: Understanding the science and taking action to reduce consumer confusion. Nutr. J. 16, 53 (2017).
pubmed: 28854932
pmcid: 5577766
doi: 10.1186/s12937-017-0271-4
Lim, J. U. et al. Comparison of world health organization and asia-pacific body mass index classifications in COPD patients. Int. J. Chron. Obstruct. Pulmon. Dis. 12, 2465–2475 (2017).
pubmed: 28860741
pmcid: 5571887
doi: 10.2147/COPD.S141295
Huang, C. et al. Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. Genes Dis. 10, 2351–2365 (2023).
pubmed: 37554175
doi: 10.1016/j.gendis.2022.04.014
Lan, N. et al. FTO—a common genetic basis for obesity and cancer. Front. Genet. 11, 559138 (2020).
pubmed: 33304380
pmcid: 7701174
doi: 10.3389/fgene.2020.559138
Zhang, Q. et al. Relationship between fat mass and obesity-associated (FTO) gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians. Med. Sci. Monit. 24, 8232–8238 (2018).
pubmed: 30442880
pmcid: 6251077
doi: 10.12659/MSM.910928
Sierra-Ruelas, E. et al. The rs9939609 variant in FTO increases the risk of hypercholesterolemia in metabolically healthy subjects with excess weight. Lifestyle Genom. 15, 131–138 (2022).
pubmed: 36183687
doi: 10.1159/000527097
Scuteri, A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007).
pubmed: 17658951
pmcid: 1934391
doi: 10.1371/journal.pgen.0030115
Chen, Y. et al. A modified formula for calculating low-density lipoprotein cholesterol values. Lipids Health Dis. 9, 52 (2010).
pubmed: 20487572
pmcid: 2890624
doi: 10.1186/1476-511X-9-52
Rauhio, A. et al. Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women. Maturitas 76, 165–171 (2013).
pubmed: 23911093
doi: 10.1016/j.maturitas.2013.07.004
Andreasen, C. H. et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57, 95–101 (2008).
pubmed: 17942823
doi: 10.2337/db07-0910
Franczak, A. et al. Association between FTO gene polymorphisms and HDL cholesterol concentration may cause higher risk of cardiovascular disease in patients with acromegaly. Pituitary 21, 10–15 (2018).
pubmed: 28913579
doi: 10.1007/s11102-017-0840-8
Khella, M. S. et al. The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: A case-control study. BMC Med. Genet. 18, 101 (2017).
pubmed: 28915859
pmcid: 5603034
doi: 10.1186/s12881-017-0461-0
Hebbar, P. et al. FTO variant rs1421085 associates with increased body weight, soft lean mass, and total body water through interaction with ghrelin and apolipoproteins in Arab population. Front. Genet. 10, 1411 (2019).
pubmed: 32076432
doi: 10.3389/fgene.2019.01411
Najd Hassan Bonab, L. et al. The role of FTO variant rs1421085 in the relationship with obesity: A systematic review and meta-analysis. Eat. Weight Disord. Stud. Anorexia Bulimia Obes. 27, 3053–3062 (2022).
doi: 10.1007/s40519-022-01509-0
Speakman, J. R. The “fat mass and obesity related” (FTO) gene: Mechanisms of impact on obesity and energy balance. Curr. Obes. Rep. 4, 73–91 (2015).
pubmed: 26627093
doi: 10.1007/s13679-015-0143-1
Liu, S. et al. Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression. J. Nutr. Biochem. 123, 109512 (2024).
pubmed: 37907171
doi: 10.1016/j.jnutbio.2023.109512
Labayen, I. et al. Association between the FTO rs9939609 polymorphism and leptin in European adolescents: A possible link with energy balance control. The HELENA study. Int. J. Obes. (Lond) 35, 66–71 (2011).
pubmed: 20975729
doi: 10.1038/ijo.2010.219
Liu, J. et al. Genetic and environmental influences on nutrient intake. Genes Nutr. 8, 241–252 (2013).
pubmed: 23055091
doi: 10.1007/s12263-012-0320-8
Malik, V. S. et al. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation 121, 1356–1364 (2010).
pubmed: 20308626
pmcid: 2862465
doi: 10.1161/CIRCULATIONAHA.109.876185
Susmiati, S. et al. Association of fat mass and obesity-associated rs9939609 polymorphisms and eating behaviour and food preferences in adolescent Minangkabau girls. Pak. J. Nutr. 17, 471–479 (2018).
doi: 10.3923/pjn.2018.471.479
Cecil, J. E. et al. An obesity-associated FTO gene variant and increased energy intake in children. N. Engl. J. Med. 359, 2558–2566 (2008).
pubmed: 19073975
doi: 10.1056/NEJMoa0803839
Melhorn, S. et al. FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr 107, 145–154 (2018).
pubmed: 29529147
pmcid: 6454473
doi: 10.1093/ajcn/nqx029
Jiao, J. The role of nutrition in obesity. Nutrients 15, 2556 (2023).
pubmed: 37299519
pmcid: 10255836
doi: 10.3390/nu15112556
Doo, M. & Kim, Y. Obesity: Interactions of genome and nutrients intake. Prev. Nutr. Food Sci. 20, 1–7 (2015).
pubmed: 25866743
pmcid: 4391534
doi: 10.3746/pnf.2015.20.1.1
Gulati, P. & Yeo, G. S. H. The biology of FTO: From nucleic acid demethylase to amino acid sensor. Diabetologia 56, 2113–2121 (2013).
pubmed: 23896822
pmcid: 3764322
doi: 10.1007/s00125-013-2999-5
Lurie, G. et al. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One 6, e16756 (2011).
pubmed: 21347432
pmcid: 3035652
doi: 10.1371/journal.pone.0016756
Karra, E. et al. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J. Clin. Invest. 123, 3539–3551 (2013).
pubmed: 23867619
pmcid: 3726147
doi: 10.1172/JCI44403
Schneeberger, M. Irx3, a new leader on obesity genetics. EBiomedicine 39, 19–20 (2019).
pubmed: 30541683
doi: 10.1016/j.ebiom.2018.12.005