Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma.
Animals
Endolymphatic Hydrops
/ metabolism
Mice
Noise
/ adverse effects
Mice, Transgenic
Cochlea
/ pathology
Hair Cells, Auditory
/ pathology
Synapses
/ metabolism
Glutamic Acid
/ metabolism
Hearing Loss, Noise-Induced
/ metabolism
Stereocilia
/ metabolism
Cochlear Nerve
/ metabolism
Meniere Disease
/ pathology
Blast Injuries
/ pathology
Hearing Loss, Hidden
Auditory nerve
Cochlea
Hair cell
Hearing
Optical coherence tomography
Osmosis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 Oct 2024
27 Oct 2024
Historique:
received:
13
08
2024
accepted:
21
10
2024
medline:
28
10
2024
pubmed:
28
10
2024
entrez:
28
10
2024
Statut:
epublish
Résumé
Endolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere's disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness. Endolymphatic hydrops also can occur after noise trauma and its presence correlates with cochlear synaptopathy, a form of hearing loss caused by reduced numbers of synapses between hair cells and auditory nerve fibers. Here we tested whether there is a mechanistic link between these two phenomena by using multimodal imaging techniques to analyze the cochleae of transgenic mice exposed to blast and osmotic challenge. In vivo cochlear imaging after blast exposure revealed dynamic increases in endolymph that involved hair cell mechanoelectrical transduction channel block but not the synaptic release of glutamate at the hair cell-auditory nerve synapse. In contrast, ex vivo and in vivo auditory nerve imaging revealed that synaptopathy requires glutamate release from hair cells but not endolymphatic hydrops. Thus, although endolymphatic hydrops and cochlear synaptopathy are both observed after noise exposure, one does not cause the other. They are simply co-existent sequelae that derive from the traumatic stimulation of hair cell stereociliary bundles. Importantly, these data argue that Meniere's disease derives from hair cell transduction channel blockade.
Identifiants
pubmed: 39465341
doi: 10.1038/s41598-024-77154-7
pii: 10.1038/s41598-024-77154-7
doi:
Substances chimiques
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25660Subventions
Organisme : NIDCD NIH HHS
ID : R01DC014450
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01DC015385
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01EB027113
Pays : United States
Informations de copyright
© 2024. The Author(s).
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