Heterologous Versus Homologous COVID-19 Boosters: Immune Response Outcomes in Renal Transplant Recipients.
Humans
Female
Male
Kidney Transplantation
/ adverse effects
Middle Aged
COVID-19
/ immunology
Prospective Studies
Antibodies, Viral
/ blood
Adult
Immunization, Secondary
Transplant Recipients
/ statistics & numerical data
COVID-19 Vaccines
/ immunology
SARS-CoV-2
/ immunology
Mycophenolic Acid
/ therapeutic use
Vaccination
Immunosuppressive Agents
/ therapeutic use
ACE inhibitor
booster vaccine
inactivated vaccine
mRNA vaccine
mycophenolic acid
renal transplantation
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Nov 2024
Nov 2024
Historique:
revised:
18
09
2024
received:
24
06
2024
accepted:
17
10
2024
medline:
28
10
2024
pubmed:
28
10
2024
entrez:
28
10
2024
Statut:
ppublish
Résumé
We aimed to investigate the immune responses to homologous and heterologous COVID-19 booster vaccinations in renal transplant recipients (RTRs) and to identify factors affecting these responses. In this prospective multicenter observational study, we measured the antibody kinetics of 90 RTRs using the chemiluminescent microparticle immunoassay method. The mean age of participants was 45.2 ± 11.4 years, with 35.6% being female. On the 42nd day after the first vaccine dose, the median antibody level was 16.7 (IQR 2.5-249.5) AU/mL, and the seropositivity rate was 60% (n = 36). Mycophenolic acid (MFA) (OR: 0.087, 95% CI: 0.024-0.311) and ACE inhibitor use (OR: 0.203, 95% CI: 0.052-0.794) were identified as independent factors affecting seropositivity. Patients who received the Pfizer/BioNTech booster had significantly higher antibody levels compared to those who received the CoronaVac/Sinovac booster (p = 0.021). Additionally, a significantly higher rate of COVID-19 positivity was observed among patients who received the CoronaVac/Sinovac booster (p = 0.031). Heterologous COVID-19 booster vaccination is significantly more effective than homologous inactivated booster vaccination in enhancing immune responses and preventing new infections in RTRs. MFA and ACE inhibitor usage were independent factors affecting seropositivity. Additional COVID-19 vaccine doses are needed in this patient group.
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Mycophenolic Acid
HU9DX48N0T
Immunosuppressive Agents
0
Types de publication
Journal Article
Observational Study
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70030Subventions
Organisme : This study was supported by Gazi Üniversitesi.
Informations de copyright
Journal of Medical Virology© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.
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