Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis.

Encephalomyelitis, Autoimmune, Experimental / immunology Animals Mucosal-Associated Invariant T Cells / immunology Receptors, Antigen, T-Cell / metabolism Mice Lymphocyte Activation / immunology Mice, Inbred C57BL Female Histocompatibility Antigens Class I / immunology Minor Histocompatibility Antigens / metabolism Multiple Sclerosis / immunology Central Nervous System / immunology Cytokines / metabolism Ribitol / analogs & derivatives Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism Uracil / analogs & derivatives

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
28 Oct 2024
Historique:
received: 08 07 2023
accepted: 18 10 2024
medline: 29 10 2024
pubmed: 29 10 2024
entrez: 29 10 2024
Statut: epublish

Résumé

Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1). Neuroinflammation in multiple sclerosis (MS) is likely initiated by autoreactive T cells and perpetuated by infiltration of additional immune cells, but the precise role of MAIT cells in MS pathogenesis remains unknown. Here, we use experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and find an accumulation of MAIT cells in the inflamed central nervous system (CNS) enriched for MAIT17 (RORγt

Identifiants

DOI: 10.1038/s41467-024-53657-9 PMID: 39468055
pubmed: 39468055
doi: 10.1038/s41467-024-53657-9
pii: 10.1038/s41467-024-53657-9
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Histocompatibility Antigens Class I 0
Minor Histocompatibility Antigens 0
Cytokines 0
5-(2-oxopropylideneamino)-6-d-ribitylaminouracil 0
Ribitol 488-81-3
Nuclear Receptor Subfamily 1, Group F, Member 3 0
Uracil 56HH86ZVCT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9287

Subventions

Organisme : Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
ID : 01GI1605C
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : Grant No. 470154978; WI 5322/2-1

Informations de copyright

© 2024. The Author(s).

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Auteurs

Mark Walkenhorst (M)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-2277-9532

Jana K Sonner (JK)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-4700-272X

Nina Meurs (N)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-5366-0123

Jan Broder Engler (JB)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-3169-2076

Simone Bauer (S)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Ingo Winschel (I)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-9487-7070

Marcel S Woo (MS)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-1306-2708

Lukas Raich (L)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Iris Winkler (I)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-6900-5139

Vanessa Vieira (V)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Lisa Unger (L)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Gabriela Salinas (G)

NGS-Integrative Genomics Core Unit, Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.

Olivier Lantz (O)

Institut National de la Santé et de la Recherche Médicale U932, PSL University, Institut Curie, Paris, France.
ORCID: 0000-0003-3161-7719

Manuel A Friese (MA)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manuel.friese@zmnh.uni-hamburg.de.
ORCID: 0000-0001-6380-2420

Anne Willing (A)

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. anne.willing@zmnh.uni-hamburg.de.
ORCID: 0000-0002-0924-2829

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Eucaryotes › Animaux › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T invariantes associées aux muqueuses › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe I › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes mineurs d'histocompatibilité › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Système nerveux › Système nerveux central › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Glucides › Polyols › Ribitol › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires › Protective effect of TCR-mediated MAIT cell...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Uracile › Protective effect of TCR-mediated MAIT cell...