Gastrointestinal and respiratory morbidity when introducing eggs as complementary food: a randomised controlled trial in South African infants.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 10 2024
29 10 2024
Historique:
received:
09
02
2024
accepted:
10
10
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
We investigated the incidence and duration of morbidity symptoms among infants aged 6 to 9 months from a low socioeconomic community receiving one egg daily for 6 months. This was a secondary outcome of a randomised controlled trial (RCT) of 500 infants conducted in Jouberton, South Africa. The primary outcome was linear growth. Morbidity data were collected weekly using a symptoms diary and qualitative data with focus group discussions at the endpoint. Ethical approval was obtained from the North-West University Health Research Ethics Committee. The intervention group had a ~ 5% higher incidence of gastrointestinal morbidity (17.0%) compared to the control group (11.9%). Gastrointestinal morbidity without fever tended to be 1.4 times higher in the intervention group (OR: 1.43, 95% CI: 1.03, 1.93; P = 0.058) and tended to be 4 times higher with fever (OR: 4.07, 95% CI: 0.86, 19.23; P = 0.077). The duration of total gastrointestinal and respiratory morbidity was 1.5 days longer in the intervention group (β: 1.491; 95% CI 0.064, 2.918; P = 0.041). Complementary feeding with eggs may have contributed towards an increased risk for gastrointestinal morbidity.
Identifiants
pubmed: 39468133
doi: 10.1038/s41598-024-76169-4
pii: 10.1038/s41598-024-76169-4
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
25881Informations de copyright
© 2024. The Author(s).
Références
World Health Organisation. Child mortality (under 5 years). https://www.who.int/news-room/fact-sheets/detail/levels-and-trends-in-child-under-5-mortality-in-2020 (2022).
Nannan, N. N. et al. Child mortality trends and causes of death in South Africa, 1997–2012, and the importance of a national burden of disease study. S Afr. Med. J.109, 480–485. https://doi.org/10.7196/SAMJ.2019.v109i7.13717 (2019).
doi: 10.7196/SAMJ.2019.v109i7.13717
pubmed: 31266573
Brown, K. H. & 328S-332S. Diarrhea and malnutrition. J. Nutr.133 https://doi.org/10.1093/jn/133.1.328S (2003).
Nel, E. Diarrhoea and malnutrition. South. Afr. J. Clin. Nutr.23, 15–18. https://doi.org/10.1080/16070658.2010.11734262 (2010).
doi: 10.1080/16070658.2010.11734262
World Health Organisation. Infant and young child feeding. https://www.who.int/news-room/fact-sheets/detail/infant-and-young-child-feeding (2023).
Department of Health, S. S. A. & South African Medical Research Council. South Africa Demographic and Health Survey 2016 (National Department of Health - NDoH - ICF, 2019).
Gizaw, Z., Woldu, W. & Bitew, B. D. Child feeding practices and diarrheal disease among children less than two years of age of the nomadic people in Hadaleala District, Afar Region, Northeast Ethiopia. Int. Breastfeed. J.12, 24. https://doi.org/10.1186/s13006-017-0115-z (2017).
doi: 10.1186/s13006-017-0115-z
pubmed: 28592985
pmcid: 5460459
Hamer, D. H. et al. Importance of breastfeeding and complementary feeding for management and prevention of childhood diarrhoea in low- and middle-income countries. J. Glob Health. 12, 10011. https://doi.org/10.7189/jogh.12.10011 (2022).
doi: 10.7189/jogh.12.10011
pubmed: 35916658
pmcid: 9344980
Ogbo, et al. Infant feeding practices and diarrhoea in sub-saharan African countries with high diarrhoea mortality. PLoS ONE12, e0171792. https://doi.org/10.1371/journal.pone.0171792 (2017).
doi: 10.1371/journal.pone.0171792
pubmed: 28192518
pmcid: 5305225
Réhault-Godbert, S., Guyot, N. & Nys, Y. The golden egg: nutritional value, bioactivities, and emerging benefits for human health. Nutrients. 11 https://doi.org/10.3390/nu11030684 (2019).
Iannotti, L. L. et al. Eggs in Early complementary feeding and child growth: a randomized controlled trial. Pediatrics 140 https://doi.org/10.1542/peds.2016-3459 (2017).
Imdad, A., Mayo-Wilson, E., Herzer, K. & Bhutta, Z. A. Vitamin a supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst. Rev. https://doi.org/10.1002/14651858.CD008524.pub3 (2017).
Ahmed, K. Y., Page, A., Arora, A. & Ogbo, F. A. Associations between infant and young child feeding practices and acute respiratory infection and diarrhoea in Ethiopia: a propensity score matching approach. PLoS ONE15, e0230978. https://doi.org/10.1371/journal.pone.0230978 (2020).
doi: 10.1371/journal.pone.0230978
pubmed: 32236145
pmcid: 7112197
Kung’u, J. K. et al. Bacterial populations in complementary foods and drinking-water in households with children aged 10–15 months in Zanzibar, Tanzania. J. Health Popul. Nutr.27, 41–52. https://doi.org/10.3329/jhpn.v27i1.3316 (2009).
doi: 10.3329/jhpn.v27i1.3316
pubmed: 19248647
pmcid: 2761806
Ogbo, F. A., Nguyen, H., Naz, S., Agho, K. E. & Page, A. The association between infant and young child feeding practices and diarrhoea in Tanzanian children. Trop. Med. Health. 46, 2. https://doi.org/10.1186/s41182-018-0084-y (2018).
doi: 10.1186/s41182-018-0084-y
pubmed: 29422772
pmcid: 5791185
Sheth, M. & Dwivedi, R. Complementary foods associated diarrhea. Indian J. Pediatr.73, 61–64. https://doi.org/10.1007/BF02758262 (2006).
doi: 10.1007/BF02758262
pubmed: 16444063
Prendergast, A. & Kelly, P. Enteropathies in the developing world: neglected effects on global health. Am. J. Trop. Med. Hyg.86, 756–763. https://doi.org/10.4269/ajtmh.2012.11-0743 (2012).
doi: 10.4269/ajtmh.2012.11-0743
pubmed: 22556071
pmcid: 3335677
Prendergast, A. J. et al. Stunting is characterized by chronic inflammation in Zimbabwean infants. PLoS One. 9, e86928. https://doi.org/10.1371/journal.pone.0086928 (2014).
doi: 10.1371/journal.pone.0086928
pubmed: 24558364
pmcid: 3928146
Kosek, M. N. Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study. EBioMedicine18, 109–117 (2017). https://doi.org/10.1016/j.ebiom.2017.02.024
Budge, S., Parker, A. H., Hutchings, P. T. & Garbutt, C. Environmental enteric dysfunction and child stunting. Nutr. Rev.77, 240–253. https://doi.org/10.1093/nutrit/nuy068 (2019).
doi: 10.1093/nutrit/nuy068
pubmed: 30753710
pmcid: 6394759
Owino, V. et al. Environmental enteric dysfunction and growth failure/stunting in Global Child Health. Pediatrics. 138 https://doi.org/10.1542/peds.2016-0641 (2016).
Muthukumar, J., Selvasekaran, P., Lokanadham, M. & Chidambaram, R. Food and food products associated with food allergy and food intolerance - an overview. Food Res. Int.138, 109780. https://doi.org/10.1016/j.foodres.2020.109780 (2020).
doi: 10.1016/j.foodres.2020.109780
pubmed: 33288166
Hossny, E. et al. Challenges of managing food allergy in the developing world. World Allergy Organ. J.12, 100089. https://doi.org/10.1016/j.waojou.2019.100089 (2019).
doi: 10.1016/j.waojou.2019.100089
pubmed: 31871534
pmcid: 6909084
Levin, M., Gray, C. & Marrugo, J. food allergy: international and developing world perspectives. Curr. Pediatr. Res.4 https://doi.org/10.1007/s40124-016-0104-5 (2016).
Botha, M., Basera, W., Facey-Thomas, H.E., Gaunt, B., Gray, C.L. et al. Rural and urban food allergy prevalence from the South African Food Allergy (SAFFA) study. J. Allergy Clin. Immunol.143, 662-668.e662. https://doi.org/10.1016/j.jaci.2018.07.023 (2019).
Lomer, M. C. E. Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance. Aliment. Pharmacol. Ther.41, 262–275. https://doi.org/10.1111/apt.13041 (2015).
doi: 10.1111/apt.13041
pubmed: 25471897
Dewey, K. G. & Adu-Afarwuah, S. Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Matern Child. Nutr.4 Suppl 1, 24–85. https://doi.org/10.1111/j.1740-8709.2007.00124.x (2008).
doi: 10.1111/j.1740-8709.2007.00124.x
pubmed: 18289157
Eaton, J. C. et al. Effectiveness of provision of animal-source foods for supporting optimal growth and development in children 6 to 59 months of age. Cochrane Database Syst. Rev. https://doi.org/10.1002/14651858.CD012818.pub2 (2019).
Iannotti, L. L. et al. Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial. Pediatrics 140, e20163459 https://doi.org:10.1542/peds.2016-3459 (2017).
Waters, W. F. et al. Cracking the Egg potential: traditional knowledge, attitudes, and practices in a food-based Nutrition intervention in Highland Ecuador. Food Nutr. Bull.39, 206–218. https://doi.org/10.1177/0379572118763182 (2018).
doi: 10.1177/0379572118763182
pubmed: 29558837
Ricci, H. et al. Effects of egg as an early complementary food on growth of 6 to 9-month-old infants: a randomised controlled trial. Public. Health Nutr. 1–29. https://doi.org/10.1017/s1368980023002604 (2023).
Department of Agriculture, Forestry and Fisheries. Regulations regarding the grading, packing and marking of eggs intended for sale in the Republic of South Africa. https://www.gov.za/sites/default/files/gcis_document/202003/43108rg11055gon345.pdf (2020)
Smuts, C. M. et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am. J. Clin. Nutr.109, 55–68. https://doi.org/10.1093/ajcn/nqy282 (2019).
doi: 10.1093/ajcn/nqy282
pubmed: 30649163
pmcid: 6358035
World Health Organization. WHO Child Growth Standards. Length/Height-for-Age, Weight-for-Age, Weight-for-Length, Weight-for-Height and Body Mass Index-for-Age: Methods and Development (WHO, 2006).
Goldman, N., Vaughan, B. & Pebley, A. R. The use of calendars to measure child illness in health interview surveys. Int. J. Epidemiol.27, 505–512. https://doi.org/10.1093/ije/27.3.505 (1998).
doi: 10.1093/ije/27.3.505
pubmed: 9698144
Checkley, W. et al. Multi-country analysis of the effects of diarrhoea on childhood stunting. Int. J. Epidemiol.37, 816–830. https://doi.org/10.1093/ije/dyn099 (2008).
doi: 10.1093/ije/dyn099
pubmed: 18567626
pmcid: 2734063
World Health Organisation. Diarrhoeal disease. https://www.who.int/news-room/fact-sheets/detail/diarrhoeal-disease (2017).
Chang, A. B., Oppenheimer, J. J. & Irwin, R. S. Managing chronic cough as a symptom in children and management algorithms: CHEST guideline and expert panel report. Chest158, 303–329. https://doi.org/10.1016/j.chest.2020.01.042 (2020).
doi: 10.1016/j.chest.2020.01.042
pubmed: 32179109
Arndt, M. B. et al. Validation of the micronutrient and environmental enteric dysfunction assessment tool and evaluation of biomarker risk factors for growth faltering and vaccine failure in young Malian children. PLoS Negl. Trop. Dis.14, e0008711. https://doi.org/10.1371/journal.pntd.0008711 (2020).
doi: 10.1371/journal.pntd.0008711
pubmed: 32997666
pmcid: 7549819
Sandelowski, M. Whatever happened to qualitative description?. Res. Nurs. Health23, 334–340. https://doi.org/10.1002/1098-240X(200008)23:4%3C;334::AID-NUR9%3E;3.0.CO;2-G (2000).
Caulfield, J. H. How to do thematic analysis | Guide & examples. https://www.scribbr.co.uk/research-methods/thematic-analysis-explained/ (2022).
Krueger, A. R. Designing and Conducting Focus Group Interviews. https://www.eiu.edu/ihec/Krueger-FocusGroupInterviews.pdf (2002).
Creswell, J. W. Research Design: Qualitative, Quantitative, and Mixed Methods Approaches (SAGE Publications, Inc., 2009).
Tango, T. Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials 1st edn (Chapman and Hall/CRC, 2017).
Namaste, S. M. & Rohner, F. Adjusting ferritin concentrations for inflammation: biomarkers reflecting inflammation and nutritional determinants of Anemia (BRINDA) project. Am. J. Clin. Nutr.106, 359s–371s. https://doi.org/10.3945/ajcn.116.141762 (2017).
doi: 10.3945/ajcn.116.141762
pubmed: 28615259
pmcid: 5490647
Omer, A., Mulualem, D., Classen, H., Vatanparast, H. & Whiting, S. Promotion of egg and eggshell powder consumption on the nutritional status of young children in Ethiopia. Int. J. Food Sci. Nutr.1 https://doi.org/10.31546/IJFSNR.1004 (2019).
Jambalang, A. R., Buys, E. M. & Botha, F. S. Bacterial species from retailed poultry eggs in Tshwane, South Africa: implication for consumers. S Afr. J. Sci.113, 1–7 (2017).
doi: 10.17159/sajs.2017/20160232
Howard, Z. R., O’Bryan, C. A., Crandall, P. G. & Ricke, S. C. Salmonella Enteritidis in shell eggs: current issues and prospects for control. Int. Food Res.45, 755–764. https://doi.org/10.1016/j.foodres.2011.04.030 (2012).
doi: 10.1016/j.foodres.2011.04.030
Caubet, J. C. & Wang, J. Current understanding of egg allergy. Pediatr. Clin. North Am. 58, 427–443, xi. https://doi.org/10.1016/j.pcl.2011.02.014 (2011).
Lindsey DeSoto, R. LD Everything You Need to Know About Egg Intolerance. https://www.verywellhealth.com/egg-intolerance-5224700 (2023).
Palacios, A. M. et al. Egg and dairy consumption were not associated with allergic reactions or Allergy-Like symptoms in 6 to 9 Month-Old infants from Rural Cotopaxi, Ecuador. FASEB J.30 674.613-674.613 (2016).
Johnson, L. F. et al. Steep declines in pediatric AIDS mortality in South Africa, despite poor progress toward pediatric diagnosis and treatment targets. Pediatr. Infect. Dis. J.39, 843–848. https://doi.org/10.1097/inf.0000000000002680 (2020).
doi: 10.1097/inf.0000000000002680
pubmed: 32433224
pmcid: 7958302
Werner, E. R. et al. The effects of one egg per day on vitamin a Status among Young Malawian children: a secondary analysis of a Randomized Controlled Trial. Curr. Dev. Nutr.7, 100053. https://doi.org/10.1016/j.cdnut.2023.100053 (2023).
doi: 10.1016/j.cdnut.2023.100053
pubmed: 37181936
pmcid: 10111603