Tacrolimus Dose Requirement in
Humans
Tacrolimus
/ administration & dosage
Kidney Transplantation
Female
Male
Middle Aged
Immunosuppressive Agents
/ administration & dosage
Adult
Prospective Studies
Kidney Failure, Chronic
/ surgery
Cytochrome P-450 CYP3A
/ metabolism
Aged
Graft Rejection
/ prevention & control
Creatinine
/ blood
Bilirubin
/ blood
Dose-Response Relationship, Drug
diet
ethnicity
genetic polymorphisms
pharmacokinetic variability
tacrolimus
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
2024
2024
Historique:
received:
04
07
2024
accepted:
20
09
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
All the factors potentially influencing tacrolimus dose requirement and combinations thereof have never been thoroughly investigated, precluding accurate prediction of tacrolimus starting dose. This prospective, non-interventional, multicenter study in
Identifiants
pubmed: 39469664
doi: 10.3389/ti.2024.13495
pii: 13495
pmc: PMC11513580
doi:
Substances chimiques
Tacrolimus
WM0HAQ4WNM
Immunosuppressive Agents
0
Cytochrome P-450 CYP3A
EC 1.14.14.1
Creatinine
AYI8EX34EU
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
13495Informations de copyright
Copyright © 2024 Marquet, Anglicheau, Humeau, Adrouche, Saada, Bisiaux, Guillemin, Lardy-Cléaud and Rostaing.
Déclaration de conflit d'intérêts
SA and LS are employees of SANDOZ S.A.S, Levallois-Perret, France, which funded the study. JB, SG, and AL-C are employees of RCTs, the contract research organization that conducted the study on behalf of SANDOZ S.A.S. AH is a biostatistician at University Hospital of Limoges, France. PM, DA, and LR received honoraria from SANDOZ S.A.S as members of the study’s independent Scientific Committee. PM is a consultant/medical expert for Astellas, BMS, Chiesi, Exeltis, MedIncell, Pfizer, Siemens and Womed. DA is a consultant/medical expert for Astellas, Astra Zeneca, BMS and Chiesi. LR is a consultant/medical expert for BMS and Sanofi.