Novel

Amyotrophic Lateral Sclerosis / metabolism Animals Mice DNA-Binding Proteins / metabolism Disease Models, Animal Humans Mice, Transgenic Genes, Reporter Oxidative Stress / drug effects NF-E2-Related Factor 2 / metabolism Drug Development DNA Damage Biomarkers
TDP-43 in vivo preclinical models reporters

Journal

Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 29 10 2024
Statut: ppublish

Résumé

The development of therapies to combat neurodegenerative diseases is widely recognized as a research priority. Despite recent advances in understanding their molecular basis, there is a lack of suitable early biomarkers to test selected compounds and accelerate their translation to clinical trials. We have investigated the utility of

Identifiants

DOI: 10.1098/rsob.240073 PMID: 39471842
pubmed: 39471842
doi: 10.1098/rsob.240073
doi:

Substances chimiques

DNA-Binding Proteins 0
NF-E2-Related Factor 2 0
TARDBP protein, human 0
Biomarkers 0
Tardbp protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

240073

Subventions

Organisme : MND Scotland
Organisme : ARUK

Auteurs

Febe Ferro (F)

Systems and Cellular Medicine, University of Dundee, Dundee DD1 9SY, UK.
ORCID: 0009-0007-1960-0208

C Roland Wolf (CR)

Systems and Cellular Medicine, University of Dundee, Dundee DD1 9SY, UK.
ORCID: 0000-0002-6969-0113

Christopher Henstridge (C)

Systems and Cellular Medicine, University of Dundee, Dundee DD1 9SY, UK.
ORCID: 0000-0002-0393-180X

Francisco Inesta-Vaquera (F)

Systems and Cellular Medicine, University of Dundee, Dundee DD1 9SY, UK.
Department of Biochemistry and Molecular Biology and Genetics, University of Extremadura, Badajoz 06006, Spain.
ORCID: 0000-0002-4579-7418

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Novel
questionsmedicales.fr › Eucaryotes › Animaux › Novel
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Novel
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Novel
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Novel
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Novel
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Novel
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Novel
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Novel
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Novel
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Novel
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Novel