Association of albumin-corrected anion gap with severe consciousness disorders and outcomes in ischemic stroke: a retrospective MIMIC analysis.
Albumin-corrected anion gap
Ischemic stroke
Mortality
Severe disorder of consciousness
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 10 2024
29 10 2024
Historique:
received:
14
08
2024
accepted:
14
10
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
The relationship between albumin-corrected anion gap (ACAG) and severe disorder of consciousness (SDOC), in-hospital mortality, and long-term mortality in patients with ischemic stroke (IS) remains unclear. This study investigates the association of ACAG with SDOC and other outcomes in IS using data from the MIMIC-IV database. A total of 2,379 IS patients were included, with a demographic breakdown showing 51% were male and an SDOC incidence of 16.4%. Analysis through Cox proportional hazards models indicated that ACAG is significantly associated with the risks of both SDOC and mortality. Additionally, restricted cubic spline(RCS) analysis suggested a nearly linear relationship between increasing ACAG levels and the incidence of SDOC. Kaplan-Meier curves demonstrated significant differences in the incidence rates of SDOC, in-hospital mortality, and long-term mortality across varying ACAG levels. The findings suggest that ACAG serves as an independent predictor for SDOC, in-hospital mortality, and long-term mortality in IS patients. Nonetheless, further prospective studies are needed to confirm these causal relationships.
Identifiants
pubmed: 39472602
doi: 10.1038/s41598-024-76324-x
pii: 10.1038/s41598-024-76324-x
doi:
Substances chimiques
Serum Albumin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26006Informations de copyright
© 2024. The Author(s).
Références
Feigin, V. L. & Owolabi, M. O. Pragmatic solutions to reduce the global burden of stroke: a world stroke organization-lancet neurology commission. Lancet Neurol. 22, 1160–1206. https://doi.org/10.1016/s1474-4422(23)00277-6 (2023).
doi: 10.1016/s1474-4422(23)00277-6
pubmed: 37827183
Tsao, C. W. et al. Heart disease and stroke statistics-2023 update: a report from the American heart association. Circulation. 147, e93–e621. https://doi.org/10.1161/cir.0000000000001123 (2023).
doi: 10.1161/cir.0000000000001123
pubmed: 36695182
Alkhachroum, A. et al. Association of acute alteration of consciousness in patients with acute ischemic stroke with outcomes and early withdrawal of care. Neurology. 98, e1470–e1478. https://doi.org/10.1212/wnl.0000000000200018 (2022).
doi: 10.1212/wnl.0000000000200018
pubmed: 35169010
pmcid: 8992606
Chen, T., Qian, Y. & Deng, X. Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients. Cardiovasc. Diabetol. 22 https://doi.org/10.1186/s12933-023-01893-6 (2023).
Wang, X. M. et al. The serum anion gap is associated with the prognosis of coronary artery bypass grafting (CABG): analysis based on the MIMIC-IV database. Eur. Rev. Med. Pharmacol. Sci. 27, 2964–2970. https://doi.org/10.26355/eurrev_202304_31928 (2023).
doi: 10.26355/eurrev_202304_31928
pubmed: 37070897
Huang, Z., Wang, S. & Yang, S. Association between serum anion gap and risk of in-hospital mortality in patients with acute heart failure. Sci. Rep. https://doi.org/10.1038/s41598-024-55658-6 (2024).
doi: 10.1038/s41598-024-55658-6
pubmed: 39468216
pmcid: 11514312
Yu, W., Wen, Y., Shao, Y., Hu, T. & Wan, X. Relationship between anion gap and in-hospital mortality in intensive care patients with liver failure: a retrospective propensity score matching analysis. Am. J. Transl Res. 16, 98–108 (2024).
doi: 10.62347/UVCX1997
pubmed: 38322565
pmcid: 10839379
Wang, S., Teng, H., Han, H. & Xu, Y. The relationship between albumin corrected anion gap levels and mortality in patients with asthma in the ICU. Sci. Rep. 13 https://doi.org/10.1038/s41598-023-44182-8 (2023).
Gao, P., Min, J., Zhong, L. & Shao, M. Association between albumin corrected anion gap and all-cause mortality in critically ill patients with acute kidney injury: a retrospective study based on MIMIC-IV database. Ren. Fail. 45 https://doi.org/10.1080/0886022x.2023.2282708 (2023).
Sheng, H. et al. The correlation between albumin-corrected anion gap and prognosis in patients with acute myocardial infarction. ESC Heart Fail. 11, 826–836. https://doi.org/10.1002/ehf2.14639 (2024).
doi: 10.1002/ehf2.14639
pubmed: 38164072
pmcid: 10966208
Zhong, L., Xie, B., Ji, X. W. & Yang, X. H. The association between albumin corrected anion gap and ICU mortality in acute kidney injury patients requiring continuous renal replacement therapy. Intern. Emerg. Med. 17, 2315–2322. https://doi.org/10.1007/s11739-022-03093-8 (2022).
doi: 10.1007/s11739-022-03093-8
pubmed: 36112320
pmcid: 9652260
Wang, R. et al. Preoperative albumin corrected anion gap is associated with in-hospital and long-term mortality in patients undergoing coronary artery bypass grafting in a retrospective cohort study. J. Thorac. Dis. 14, 4894–4903. https://doi.org/10.21037/jtd-22-1633 (2022).
doi: 10.21037/jtd-22-1633
pubmed: 36647463
pmcid: 9840039
Hu, T., Zhang, Z. & Jiang, Y. Albumin corrected anion gap for predicting in-hospital mortality among intensive care patients with sepsis: a retrospective propensity score matching analysis. Clin. Chim. Acta. 521, 272–277. https://doi.org/10.1016/j.cca.2021.07.021 (2021).
doi: 10.1016/j.cca.2021.07.021
pubmed: 34303712
Chen, X. et al. Association between serum anion gap and mortality in critically ill patients with COPD in ICU: data from the MIMIC IV Database. Int. J. Chronic Obstruct Pulmonary Dis. 19, 579–587. https://doi.org/10.2147/copd.S433619 (2024).
doi: 10.2147/copd.S433619
Figge, J., Jabor, A., Kazda, A. & Fencl, V. Anion gap and hypoalbuminemia. Crit. Care Med. 26, 1807–1810. https://doi.org/10.1097/00003246-199811000-00019 (1998).
doi: 10.1097/00003246-199811000-00019
pubmed: 9824071
Powers, W. J. et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke. 50, e344–e418. https://doi.org/10.1161/str.0000000000000211 (2019).
doi: 10.1161/str.0000000000000211
pubmed: 31662037
Majoie, C. B. et al. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials. Lancet (London England). 402, 965–974. https://doi.org/10.1016/s0140-6736(23)01142-x (2023).
doi: 10.1016/s0140-6736(23)01142-x
pubmed: 37640037
Fan, J. et al. Global burden, risk factor analysis, and prediction study of ischemic stroke, 1990–2030. Neurology. 101, e137–e. https://doi.org/10.1212/wnl.0000000000207387 (2023).
doi: 10.1212/wnl.0000000000207387
pubmed: 37197995
pmcid: 10351546
Yin, F. et al. Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: a retrospective study based on MIMIC-III and IV databases. PloS One. 19, e0300012. https://doi.org/10.1371/journal.pone.0300012 (2024).
doi: 10.1371/journal.pone.0300012
pubmed: 38452113
pmcid: 10919588
Guo, H. & Wang, J. Association between albumin-corrected anion gap and in-hospital mortality and sepsis-associated acute kidney injury. Med. Sci. Monit. 30, e943012. https://doi.org/10.12659/msm.943012 (2024).
doi: 10.12659/msm.943012
pubmed: 38339777
pmcid: 10865774
Zhao, X. et al. Association between albumin-corrected anion gap level and the risk of acute kidney injury in intensive care unit. Int. Urol. Nephrol. 56, 1117–1127. https://doi.org/10.1007/s11255-023-03755-2 (2024).
doi: 10.1007/s11255-023-03755-2
pubmed: 37642797
Wang, R., Rong, J., Xu, J. & He, M. A prognostic model incorporating the albumin-corrected anion gap in patients with aneurysmal subarachnoid hemorrhage. Front. Neurol. 15 https://doi.org/10.3389/fneur.2024.1361888 (2024).
Lu, Y., Zhan, Y. Z., Li, W. & Liao, S. L. Relationship between albumin-corrected anion gap and non-alcoholic fatty liver disease varied in different waist circumference groups: a cross-sectional study. Eur. J. Med. Res. 29 https://doi.org/10.1186/s40001-024-01811-w (2024).
Yao, H., Tian, J. & Cheng, S. Association of anion gap and albumin corrected anion gap with acute kidney injury in patients with acute ischemic stroke. Adv. Clin. Exp. Med. https://doi.org/10.17219/acem/186814 (2024).
doi: 10.17219/acem/186814
pubmed: 38860714
Fang, L. et al. Development and validation of a nomogram for predicting 28-day mortality in patients with ischemic stroke. PLoS One. 19, e0302227. https://doi.org/10.1371/journal.pone.0302227 (2024).
doi: 10.1371/journal.pone.0302227
pubmed: 38656987
pmcid: 11042708
Chang, C. W. J., Provencio, J. J. & Shah, S. Neurological critical care: the evolution of cerebrovascular critical care. Crit. Care Med. 49, 881–900. https://doi.org/10.1097/ccm.0000000000004933 (2021).
doi: 10.1097/ccm.0000000000004933
pubmed: 33653976
Cai, W. et al. Association of glycemic variability with death and severe consciousness disturbance among critically ill patients with cerebrovascular disease: analysis of the MIMIC-IV database. Cardiovasc. Diabetol. 22 https://doi.org/10.1186/s12933-023-02048-3 (2023).