Association between SMOFlipid and impaired brain development on term-equivalent age brain magnetic resonance imaging in very preterm infants.
Humans
Infant, Newborn
Magnetic Resonance Imaging
/ methods
Soybean Oil
/ administration & dosage
Male
Female
Fat Emulsions, Intravenous
/ administration & dosage
Brain
/ diagnostic imaging
Olive Oil
Fish Oils
/ administration & dosage
Triglycerides
Infant, Extremely Premature
/ growth & development
Infant, Premature
/ growth & development
Retrospective Studies
Brain morphology
Growth
Lipid emulsion
Magnetic resonance imaging
Parenteral nutrition
Premature infant
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
29 Oct 2024
29 Oct 2024
Historique:
received:
22
09
2023
accepted:
16
10
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOFlipid) is used without evidence of benefits. We investigated the relationship between lipid emulsions and brain injury in term-equivalent age magnetic resonance imaging (MRI) in 148 very preterm infants with a birth weight of < 1500 g at ≤ 32 gestational weeks in a neonatal intensive care unit. Infants who received soybean-based lipid emulsions between January 2015 and December 2018 were compared with those who received SMOFlipids between January 2019 and December 2022. A negative binomial generalized linear model was applied for bivariate analysis. Modified log-Poisson regression with generalized linear models and a robust variance estimator (Huber-White) were applied to adjust for potential confounders. The Kidokoro score was used to determine if lipid emulsion type would affect brain morphology and growth at term-equivalent age. Eighty-six (58.9%) received SMOFlipid. SMOFlipid was associated with lower focal signal abnormality, myelination delay, increased extracerebral space, and cerebellar volume reduction (P = 0.02, P = 0.007, P = 0.01, P = 0.02, respectively). SMOFlipidis are associated with brain insult, especially in white matter, cortical gray matter, and the cerebellum. Well-designed studies are needed to investigate the effect of lipid emulsions on the central nervous system.
Identifiants
pubmed: 39472810
doi: 10.1186/s12887-024-05153-8
pii: 10.1186/s12887-024-05153-8
doi:
Substances chimiques
Soybean Oil
8001-22-7
Fat Emulsions, Intravenous
0
Olive Oil
0
Fish Oils
0
Triglycerides
0
SMOFlipid
C9H2L21V7U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
686Informations de copyright
© 2024. The Author(s).
Références
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