Exploring the relationship between ventricular fibrillation recurrence after defibrillation in myocardial infarction and the effectiveness of renal sympathetic denervation therapy.
Animals
Ventricular Fibrillation
/ physiopathology
Sympathectomy
Kidney
/ innervation
Recurrence
Myocardial Infarction
/ physiopathology
Disease Models, Animal
Male
Electric Countershock
Time Factors
Myocardium
/ pathology
Action Potentials
Electrocardiography
Heart Rate
Sympathetic Nervous System
/ physiopathology
Neurotransmitter Agents
/ metabolism
Rats, Sprague-Dawley
Fibrosis
Defibrillation treatment
Early recurrence
Electrophysiological markers
Myocardial infarction
Sympathetic renal denervation
Ventricular fibrillation
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
29 Oct 2024
29 Oct 2024
Historique:
received:
31
12
2023
accepted:
27
09
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
This study aimed to explore the association between electrophysiological markers of early recurrence after defibrillation in post-myocardial infarction ventricular fibrillation and the therapeutic effects of sympathetic renal denervation, as well as to investigate the potential underlying mechanisms. Experimental research was conducted using an animal model. Myocardial infarction was induced, followed by defibrillation treatment for ventricular fibrillation cases, and the electrophysiological markers of early recurrence were recorded. Subsequently, a subset of animals underwent sympathetic renal denervation intervention, and the therapeutic effects were compared between the sympathetic renal denervation group and the control group. Electrocardiogram monitoring, histological analysis of myocardial tissue, and neurotransmitter measurements were also performed. Following defibrillation treatment, early recurrence was observed in ventricular fibrillation cases. The electrophysiological markers revealed significantly higher ST segment elevation and T wave changes in the early recurrence group. However, in the sympathetic renal denervation intervention group, the early recurrence rate was significantly reduced, and the electrocardiogram showed improved stability and regularity. Additionally, histological analysis of myocardial tissue demonstrated less cellular damage and lower levels of myocardial fibrosis in the sympathetic renal denervation group. Neurotransmitter measurements revealed a significant decrease in sympathetic nerve activity in the sympathetic renal denervation intervention group. The results of this study indicate an association between electrophysiological markers of early recurrence after defibrillation in post-myocardial infarction ventricular fibrillation and the therapeutic effects of sympathetic renal denervation. Sympathetic renal denervation intervention can significantly reduce the early recurrence rate, improve electrocardiogram characteristics, and alleviate myocardial damage and fibrosis. Furthermore, the reduction in sympathetic nerve activity may be one of the potential underlying mechanisms of sympathetic renal denervation intervention.
Identifiants
pubmed: 39472838
doi: 10.1186/s12872-024-04222-1
pii: 10.1186/s12872-024-04222-1
doi:
Substances chimiques
Neurotransmitter Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
604Subventions
Organisme : Shanghai Municipal Health Commission Fund
ID : 201940390
Informations de copyright
© 2024. The Author(s).
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