Association of hemoglobin-to-red blood cell distribution width ratio and bone mineral density in older adults.
Bone Mineral Density
Hemoglobin
Hemoglobin-to-red cell distribution width ratio
Osteoporosis
Red cell distribution width
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
13
06
2024
accepted:
21
10
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) represents novel prognostic markers for diseases. However, there remains a lack of systematic research into the relationship between HRR and Bone Mineral Density (BMD) or osteoporosis in older adults. This study utilized information from the NHANES database, selecting individuals over 50 years of age with complete femoral DXA scans and full blood counts. The relationship between HRR and femoral BMD was investigated using weighted linear models and restricted cubic spline (RCS) models. Moreover, the association between HRR and osteoporosis was further explored using logistic regression models and RCS models, with subgroup analysis conducted to test the robustness of the results. This study included a total of 7,149 participants, and the BMD of the group with higher HRR was significantly greater than that of the group with lower HRR. Weighted linear regression analysis found a linear positive correlation between HRR and femoral BMD. When HRR was converted from a continuous variable to a categorical variable, this relationship remained stable. In addition, multivariate logistic regression analysis showed that for each 1-unit increase in HRR, the prevalence of osteoporosis significantly decreased (OR = 0.25, 95% CI: 0.12-0.51), further confirming the findings of this study. Subgroup analysis showed that this association was not significantly affected by confounding factors across different populations. HRR may serve as one of the potential indicators for evaluating BMD and assessing the prevalence of osteoporosis in the elderly. Elevating HRR levels may play a crucial role in the prevention and slowing of osteoporosis progression.
Sections du résumé
BACKGROUND
BACKGROUND
Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) represents novel prognostic markers for diseases. However, there remains a lack of systematic research into the relationship between HRR and Bone Mineral Density (BMD) or osteoporosis in older adults.
METHODS
METHODS
This study utilized information from the NHANES database, selecting individuals over 50 years of age with complete femoral DXA scans and full blood counts. The relationship between HRR and femoral BMD was investigated using weighted linear models and restricted cubic spline (RCS) models. Moreover, the association between HRR and osteoporosis was further explored using logistic regression models and RCS models, with subgroup analysis conducted to test the robustness of the results.
RESULTS
RESULTS
This study included a total of 7,149 participants, and the BMD of the group with higher HRR was significantly greater than that of the group with lower HRR. Weighted linear regression analysis found a linear positive correlation between HRR and femoral BMD. When HRR was converted from a continuous variable to a categorical variable, this relationship remained stable. In addition, multivariate logistic regression analysis showed that for each 1-unit increase in HRR, the prevalence of osteoporosis significantly decreased (OR = 0.25, 95% CI: 0.12-0.51), further confirming the findings of this study. Subgroup analysis showed that this association was not significantly affected by confounding factors across different populations.
CONCLUSION
CONCLUSIONS
HRR may serve as one of the potential indicators for evaluating BMD and assessing the prevalence of osteoporosis in the elderly. Elevating HRR levels may play a crucial role in the prevention and slowing of osteoporosis progression.
Identifiants
pubmed: 39472899
doi: 10.1186/s12891-024-07984-z
pii: 10.1186/s12891-024-07984-z
doi:
Substances chimiques
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
866Informations de copyright
© 2024. The Author(s).
Références
ESC Heart Fail. 2023 Apr;10(2):834-845
pubmed: 36460487
Front Cardiovasc Med. 2021 Aug 27;8:728800
pubmed: 34513961
Oncotarget. 2016 Jul 5;7(27):42650-42660
pubmed: 27223088
Nutrients. 2017 May 17;9(5):
pubmed: 28513571
Bone. 2017 Nov;104:39-43
pubmed: 28041872
Biochem Med (Zagreb). 2021 Oct 15;31(3):030501
pubmed: 34658642
Front Immunol. 2022 Oct 17;13:997853
pubmed: 36325342
PLoS One. 2023 Mar 16;18(3):e0283014
pubmed: 36928028
Med Clin North Am. 2021 Nov;105(6):1117-1134
pubmed: 34688418
Endocrinol Metab Clin North Am. 2023 Jun;52(2):259-275
pubmed: 36948779
Int J Mol Sci. 2023 Feb 09;24(4):
pubmed: 36834895
JAMA. 2018 Nov 20;320(19):2020-2028
pubmed: 30418471
Mol Aspects Med. 2022 Apr;84:101022
pubmed: 34509280
Int J Cardiol. 2024 Jan 1;394:131368
pubmed: 37739043
Med Clin North Am. 2020 Sep;104(5):873-884
pubmed: 32773051
Osteoporos Int. 2022 Oct;33(10):2049-2102
pubmed: 35478046
Front Public Health. 2023 Apr 13;11:1073968
pubmed: 37124822
Int J Mol Sci. 2023 Feb 14;24(4):
pubmed: 36835184
Clin Orthop Relat Res. 2000 Mar;(372):139-50
pubmed: 10738423
Nutr Diabetes. 2022 Apr 12;12(1):19
pubmed: 35414128
J Bone Miner Res. 2020 May;35(5):869-874
pubmed: 31991005
Osteoporos Int. 2016 Jan;27(1):367-76
pubmed: 26510847
Br Med Bull. 2020 May 15;133(1):105-117
pubmed: 32282039
Future Oncol. 2021 Oct;17(29):3853-3864
pubmed: 34382414
J Clin Med. 2022 Mar 31;11(7):
pubmed: 35407558
Sci Rep. 2023 Jun 7;13(1):9223
pubmed: 37286717
Eur J Appl Physiol. 2019 Jan;119(1):29-47
pubmed: 30377780
ESC Heart Fail. 2022 Oct;9(5):3210-3220
pubmed: 35768950
Bone. 2019 Mar;120:321-326
pubmed: 30448304
Crit Rev Clin Lab Sci. 2015;52(2):86-105
pubmed: 25535770
J Bone Miner Res. 2014 Nov;29(11):2520-6
pubmed: 24771492