Hemoglobin and hematocrit levels are positively correlated with phase angle in mixed cancer patients: an exploratory cross-sectional study.
Bioelectrical impedance analysis
Neoplasms
Phase angle
Red-cells
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
19
12
2023
accepted:
21
10
2024
medline:
31
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
The aim of this study is to verify the correlation between hemoglobin (Hb) and hematocrit (Ht) levels with phase angle (PhA) values in patients with cancer of the gastrointestinal tract and accessory digestive organs. A cross-sectional study was conducted with 82 patients (38 females/44 males) diagnosed with cancer of gastrointestinal tract and accessory organs of digestion. Hb (g/dL) and Ht (%) levels were assessed by the cyanomethemoglobin and microhematocrit methods, respectively. Body composition and PhA were evaluated by the bioelectrical impedance analysis (BIA). The cut-off point used to classify patients with low PhA was set < 4°. Fifty-five (67%) of patients had PhA ≥ 4° values. We observed that body weight, BMI, fat mass, % weight loss, Ht, and Hb were higher in the PhA ≥ 4° group than in the PhA < 4° group. In the regression analysis, we found a positive association between PhA, Ht, and Hb without and after adjustment for sex, age, BMI, and type of treatment. In mixed cancer patients, there was a positive correlation between blood-red cell markers and PhA. This may be evidence that we can use of hematological parameters to suggest changes in PhA values during oncological treatment.
Identifiants
pubmed: 39476216
doi: 10.1007/s00520-024-08954-w
pii: 10.1007/s00520-024-08954-w
doi:
Substances chimiques
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
757Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Lanser L, Fuchs D, Kurz K, Weiss G (2021) Physiology and inflammation driven pathophysiology of iron homeostasis-mechanistic insights into anemia of inflammation and its treatment. Nutrients 13(11):3732. https://doi.org/10.3390/nu13113732
doi: 10.3390/nu13113732
pubmed: 34835988
pmcid: 8619077
Jung DH, Lee HJ, Han DS et al (2013) Impact of perioperative hemoglobin levels on postoperative outcomes in gastric cancer surgery. Gastric Cancer 16(3):377–382. https://doi.org/10.1007/s10120-012-0196-8
doi: 10.1007/s10120-012-0196-8
pubmed: 23007652
Zhang X, Zhang F, Qiao W, Zhang X, Zhao Z, Li M (2018) Low hematocrit is a strong predictor of poor prognosis in lung cancer patients. Biomed Res Int 17(2018):6804938. https://doi.org/10.1155/2018/6804938
doi: 10.1155/2018/6804938
Ristescu I, Pintilie G, Filip D et al (2019) Perioperative anemia and transfusion in colorectal cancer patients. Chirurgia (Bucur) 114(2):234–242. https://doi.org/10.21614/chirurgia.114.2.234
doi: 10.21614/chirurgia.114.2.234
pubmed: 31060656
Razzaghdoust A, Mofid B, Peyghambarlou P (2020) Predictors of chemotherapy-induced severe anemia in cancer patients receiving chemotherapy. Support Care Cancer 28(1):155–161. https://doi.org/10.1007/s00520-019-04780-7
doi: 10.1007/s00520-019-04780-7
pubmed: 30993448
Gupta D, Lis CG, Dahlk SL, Vashi PG, Grutsch JF, Lammersfeld CA (2004) Bioelectrical impedance phase angle as a prognostic indicator in advanced pancreatic cancer. Br J Nutr 92(6):957–962. https://doi.org/10.1079/bjn20041292
doi: 10.1079/bjn20041292
pubmed: 15613258
Norman K, Stobäus N, Pirlich M, Bosy-Westphal A (2012) Bioelectrical phase angle and impedance vector analysis–clinical relevance and applicability of impedance parameters. Clin Nutr 31(6):854–861. https://doi.org/10.1016/j.clnu.2012.05.008
doi: 10.1016/j.clnu.2012.05.008
pubmed: 22698802
Bellido D, García-García C, Talluri A, Lukaski HC, García-Almeida JM (2023) Future lines of research on phase angle: strengths and limitations. Rev Endocr Metab Disord 24(3):563–583. https://doi.org/10.1007/s11154-023-09803-7
doi: 10.1007/s11154-023-09803-7
pubmed: 37043140
Gutiérrez-Santamaría B, Martinez Aguirre-Betolaza A, García-Álvarez A, Arietaleanizbeaskoa MS, Mendizabal-Gallastegui N, Grandes G, Castañeda-Babarro A, Coca A (2023) Association between PhA and physical performance variables in cancer patients. Int J Environ Res Public Health 20(2):1145. https://doi.org/10.3390/ijerph20021145
doi: 10.3390/ijerph20021145
pubmed: 36673900
pmcid: 9859119
Arab A, Karimi E, Vingrys K, Shirani F (2021) Is phase angle a valuable prognostic tool in cancer patients’ survival? A systematic review and meta-analysis of available literature. Clin Nutr 40(5):3182–3190. https://doi.org/10.1016/j.clnu.2021.01.027
doi: 10.1016/j.clnu.2021.01.027
pubmed: 33581951
Miura T, Matsumoto Y, Kawaguchi T et al (2019) Low phase angle is correlated with worse general condition in patients with advanced cancer. Nutr Cancer 71(1):83–88. https://doi.org/10.1080/01635581.2018.1557216
doi: 10.1080/01635581.2018.1557216
pubmed: 30686055
Blackburn GL, Bistrian BR, Maini BS, Schlamm HT, Smith MF (1977) Nutritional and metabolic assessment of the hospitalized patient. JPEN J Parenter Enteral Nutr 1(1):11–22. https://doi.org/10.1177/014860717700100101
doi: 10.1177/014860717700100101
pubmed: 98649
Schag CC, Heinrich RL, Ganz PA (1984) Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol 2(3):187–193
doi: 10.1200/JCO.1984.2.3.187
pubmed: 6699671
Bosy-Westphal A, Jensen B, Braun W, Pourhassan M, Gallagher D, Müller MJ (2017) Quantification of whole-body and segmental skeletal muscle mass using phase-sensitive 8-electrode medical bioelectrical impedance devices. Eur J Clin Nutr 71(9):1061–1067. https://doi.org/10.1038/ejcn.2017.27
doi: 10.1038/ejcn.2017.27
pubmed: 28327564
pmcid: 5589975
Sergi G, De Rui M, Stubbs B, Veronese N, Manzato E (2017) Measurement of lean body mass using bioelectrical impedance analysis: a consideration of the pros and cons. Aging Clin Exp Res 29(4):591–597. https://doi.org/10.1007/s40520-016-0622-6
doi: 10.1007/s40520-016-0622-6
pubmed: 27568020
Simundic AM, Cornes M, Grankvist K, Lippi G, Nybo M (2014) Standardization of collection requirements for fasting samples: for the Working Group on Preanalytical Phase (WG-PA) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). Clin Chim Acta 15(432):33–37. https://doi.org/10.1016/j.cca.2013.11.008
doi: 10.1016/j.cca.2013.11.008
Gomes TLN, Soares JDP, Borges TC, Pichard C, Pimentel GD (2020) Phase angle is not associated with fatigue in cancer patients: the hydration impact. Eur J Clin Nutr 74(9):1369–1373. https://doi.org/10.1038/s41430-020-0597-4
doi: 10.1038/s41430-020-0597-4
pubmed: 32123343
Navigante A, Morgado PC, Casbarien O, Delgado NL, Giglio R, Perman M (2013) Relationship between weakness and phase angle in advanced cancer patients with fatigue. Support Care Cancer 21(6):1685–1690. https://doi.org/10.1007/s00520-012-1714-2
doi: 10.1007/s00520-012-1714-2
pubmed: 23321933
Kyle UG, Genton L, Pichard C (2013) Low phase angle determined by bioelectrical impedance analysis is associated with malnutrition and nutritional risk at hospital admission. Clin Nutr 32(2):294–299. https://doi.org/10.1016/j.clnu.2012.08.001
doi: 10.1016/j.clnu.2012.08.001
pubmed: 22921419
Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis [published correction appears in Age Ageing. 2019 Jul 1;48(4):601]. Age Ageing 48(1):16–31. https://doi.org/10.1093/ageing/afy169 .
Xie X, Yao M, Chen X et al (2015) Reduced red blood cell count predicts poor survival after surgery in patients with primary liver cancer. Medicine (Baltimore) 94(8):e577. https://doi.org/10.1097/MD.0000000000000577
doi: 10.1097/MD.0000000000000577
pubmed: 25715259
Wei R, Du X, Wang J et al (2022) Risk and prognosis of subsequent primary gastric cancer. Oncol Res Treat 45(4):186–196. https://doi.org/10.1159/000521846
doi: 10.1159/000521846
pubmed: 34999589
Guo J, Chen S, Chen Y, Li S, Xu D (2018Feb) Combination of CRP and NLR: a better predictor of postoperative survival in patients with gastric cancer. Cancer Manag Res 14(10):315–321. https://doi.org/10.2147/CMAR.S156071
doi: 10.2147/CMAR.S156071