Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity.
Humans
Sinusitis
/ microbiology
Enterotoxins
Female
Male
Chronic Disease
Rhinitis
/ blood
Middle Aged
Adult
Staphylococcus aureus
Nasal Polyps
/ complications
Retrospective Studies
Smell
/ physiology
Immunoglobulin E
/ blood
Aged
Olfaction Disorders
Adolescent
Case-Control Studies
Staphylococcal Infections
/ microbiology
Young Adult
Rhinosinusitis
Nasal polyps
Rhinosinusitis
Sensitisation
Smell (olfaction)
Staphylococcal enterotoxins
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 10 2024
30 10 2024
Historique:
received:
28
05
2024
accepted:
22
10
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
To investigate disparities in sensitisation to Staphylococcus aureus enterotoxin A/B (SEA/SEB) and olfactory function in patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), those with CRS without nasal polyps (CRSsNP), and healthy controls who underwent septoplasty only. We retrospectively reviewed the medical records of 388 subjects aged ≥ 8 years, collected between January 2021 and June 2023. We analysed patient demographics, medical history, serum IgE levels against staphylococcal enterotoxins (SEs), and serum total IgE levels against inhalant allergens. We performed olfactory and taste function tests in the participants to evaluate the relationship between olfactory function and SEs. Of 388 patients enrolled, 145 were healthy controls, 111 had CRSsNP, and 133 had CRSwNP. The prevalence of SEA/SEB positivity was significantly higher among the patients with CRSwNP than among those in the CRSsNP and healthy controls. The olfactory test results showed significant differences among the groups; anosmia was observed in 9.7% of healthy controls, 22.7% of patients with CRSsNP, and 45.1% of patients with CRSwNP. Olfactory threshold deterioration was evident in patients with CRS. Distinction and identification were more impaired in patients with CRSwNP than in those of the other groups. Finally, the olfactory function scores decreased as the serum levels of SEs increased. Sinusitis patients seem to suffer from perceiving odours, and patients with CRSwNP have difficulty distinguishing odours. Olfactory function test scores decreased in patients with a history of asthma, and as serum levels of staphylococcus enterotoxin and blood eosinophil percentage increase. Furthermore, our result suggests a potential role for SE sensitisation and eosinophil percentage in deteriorating olfaction, especially in patients with CRSwNP.
Identifiants
pubmed: 39478131
doi: 10.1038/s41598-024-77459-7
pii: 10.1038/s41598-024-77459-7
doi:
Substances chimiques
Enterotoxins
0
enterotoxin A, Staphylococcal
37337-57-8
Immunoglobulin E
37341-29-0
enterotoxin B, staphylococcal
39424-53-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26138Informations de copyright
© 2024. The Author(s).
Références
Fokkens, W. J. et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 58 (Suppl S29), 1–464 (2020).
pubmed: 32078669
Kim, Y. S. et al. Prevalence and risk factors of chronic rhinosinusitis in Korea. Am. J. Rhinol Allergy 25 (3), 117–121. https://doi.org/10.2500/ajra.2011.25.3630 (2011).
doi: 10.2500/ajra.2011.25.3630
pubmed: 21679523
We, J. et al. Prevalence of nasal polyps and its risk factors: Korean National Health and Nutrition Examination survey 2009–2011. Am. J. Rhinol. Allergy 29 (1), e24–e28. https://doi.org/10.2500/ajra.2015.29.4131 (2015).
doi: 10.2500/ajra.2015.29.4131
pubmed: 25590312
Reden, J. et al. A study on the prognostic significance of qualitative olfactory dysfunction. Eur. Arch. Otorhinolaryngol. 264 (2), 139–144. https://doi.org/10.1007/s00405-006-0157-0 (2007).
doi: 10.1007/s00405-006-0157-0
pubmed: 17006637
Kohli, P. et al. The prevalence of olfactory dysfunction in chronic rhinosinusitis. Laryngoscope 127 (2), 309–320. https://doi.org/10.1002/lary.26316 (2017).
doi: 10.1002/lary.26316
pubmed: 27873345
Litvack, J. R., Mace, J. C. & Smith, T. L. Olfactory function and disease severity in chronic rhinosinusitis. Am. J. Rhinol Allergy 23 (2), 139–144. https://doi.org/10.2500/ajra.2009.23.3286 (2009).
doi: 10.2500/ajra.2009.23.3286
pubmed: 19401037
Qureshi, H. A. & Lane, A. P. Olfaction now and in the future in CRSwNP. Am. J. Rhinol Allergy 37 (2), 168–174. https://doi.org/10.1177/19458924231153485 (2023).
doi: 10.1177/19458924231153485
pubmed: 36848279
Fraser, J. D. & Proft, T. The bacterial superantigen and superantigen-like proteins. Immunol. Rev. 225, 226–243. https://doi.org/10.1111/j.1600-065X.2008.00681.x (2008).
doi: 10.1111/j.1600-065X.2008.00681.x
pubmed: 18837785
Huvenne, W., Hellings, P. W. & Bachert, C. Role of staphylococcal superantigens in airway disease. Int. Arch. Allergy Immunol. 161 (4), 304–314. https://doi.org/10.1159/000350329 (2013).
doi: 10.1159/000350329
pubmed: 23689556
Rha, M. S. et al. Superantigen-related TH2 CD4 + T cells in nonasthmatic chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol. 145 (5), 1378–1388e10. https://doi.org/10.1016/j.jaci.2019.12.915 (2020).
doi: 10.1016/j.jaci.2019.12.915
pubmed: 31987845
Bachert, C. & Akdis, C. A. Phenotypes and emerging endotypes of chronic rhinosinusitis. J. Allergy Clin. Immunol. Pract. 4 (4), 621–628. https://doi.org/10.1016/j.jaip.2016.05.004 (2016).
doi: 10.1016/j.jaip.2016.05.004
pubmed: 27393777
Wang, M. et al. Association of periostin expression with eosinophilic inflammation in nasal polyps. J. Allergy Clin. Immunol. 136 (6), 1700–1703e9. https://doi.org/10.1016/j.jaci.2015.09.005 (2015).
doi: 10.1016/j.jaci.2015.09.005
pubmed: 26521039
Kato, A. Immunopathology of chronic rhinosinusitis. Allergol. Int. 64 (2), 121–130. https://doi.org/10.1016/j.alit.2014.12.006 (2015).
doi: 10.1016/j.alit.2014.12.006
pubmed: 25838086
pmcid: 4675657
Choi, J. Y. et al. Current status of asthma care in South Korea: nationwide the Health Insurance Review and Assessment Service database. J. Thorac. Dis. 9 (9), 3208–3214. https://doi.org/10.21037/jtd.2017.08.109 (2017).
doi: 10.21037/jtd.2017.08.109
pubmed: 29221297
pmcid: 5708454
Korea, N. T. C. C. R. Prevalence of tobacco use. https://nosmk.khepi.or.kr/ntcc/eng/subIndex/547.do (2023).
Lee, J. H. et al. Increased levels of serum-specific immunoglobulin E to staphylococcal enterotoxin a and B in patients with allergic rhinitis and bronchial asthma. Int. Arch. Allergy Immunol. 138 (4), 305–311. https://doi.org/10.1159/000088868 (2005).
doi: 10.1159/000088868
pubmed: 16224190
Wiersma, V. R. et al. The decrease in serum sRAGE levels upon smoking is associated with activated neutrophils. Lung 200 (6), 687–690. https://doi.org/10.1007/s00408-022-00585-4 (2022).
doi: 10.1007/s00408-022-00585-4
pubmed: 36282357
pmcid: 9675764
Nagasaki, T. et al. Sensitization to Staphylococcus aureus enterotoxins in smokers with asthma. Ann. Allergy Asthma Immunol. 119 (5), 408–414e2. https://doi.org/10.1016/j.anai.2017.08.001 (2017).
doi: 10.1016/j.anai.2017.08.001
pubmed: 29150068
Chéruel, F., Jarlier, M. & Sancho-Garnier, H. Effect of cigarette smoke on gustatory sensitivity, evaluation of the deficit and of the recovery time-course after smoking cessation. Tob. Induc. Dis. 15, 15. https://doi.org/10.1186/s12971-017-0120-4 (2017).
doi: 10.1186/s12971-017-0120-4
pubmed: 28261024
pmcid: 5329949
Fjaeldstad, A. W., Ovesen, T. & Hummel, T. The association between smoking on olfactory dysfunction in 3,900 patients with olfactory loss. Laryngoscope 131 (1), E8–E13. https://doi.org/10.1002/lary.28552 (2021).
doi: 10.1002/lary.28552
pubmed: 32096874
Djordjevic, J. et al. Olfaction in patients with mild cognitive impairment and Alzheimer’s disease. Neurobiol. Aging 29 (5), 693–706. https://doi.org/10.1016/j.neurobiolaging.2006.11.014 (2008).
doi: 10.1016/j.neurobiolaging.2006.11.014
pubmed: 17207898
Ehi, Y. & Ozlece, H. K. Electrophysiological assessment of the concentration and attention in patient with nasal polyposis. Asia Pac. Allergy 8 (3), e27. https://doi.org/10.5415/apallergy.2018.8.e27 (2018).
doi: 10.5415/apallergy.2018.8.e27
pubmed: 30079305
pmcid: 6073176
Rhyou, H. I., Bae, W. Y. & Nam, Y. H. Association between olfactory function and asthma in adults. J. Asthma Allergy 14, 309–316. https://doi.org/10.2147/JAA.S299796 (2021).
doi: 10.2147/JAA.S299796
pubmed: 33833532
pmcid: 8020128
Stinton, N. et al. Influence of smell loss on taste function. Behav. Neurosci. 124 (2), 256–264. https://doi.org/10.1037/a0018766 (2010).
doi: 10.1037/a0018766
pubmed: 20364885
Othieno, F. et al. Taste impairment in chronic rhinosinusitis. Int. Forum Allergy Rhinol. 8 (7), 783–789. https://doi.org/10.1002/alr.22113 (2018).
doi: 10.1002/alr.22113
pubmed: 29569385
pmcid: 6582951
Ahn, S. H. et al. Comparison of olfactory and taste functions between eosinophilic and non-eosinophilic chronic rhinosinusitis. Auris Nasus Larynx 47 (5), 820–827. https://doi.org/10.1016/j.anl.2020.04.006 (2020).
doi: 10.1016/j.anl.2020.04.006
pubmed: 32386824
Herbert, R. P. et al. Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway. J. Neuroinflamm. 9, 109. https://doi.org/10.1186/1742-2094-9-109 (2012).
doi: 10.1186/1742-2094-9-109
Han, X. et al. Disturbed microbiota-metabolites-immune interaction network is associated with olfactory dysfunction in patients with chronic rhinosinusitis. Front. Immunol. 14, 1159112. https://doi.org/10.3389/fimmu.2023.1159112 (2023).
doi: 10.3389/fimmu.2023.1159112
pubmed: 37292198
pmcid: 10245275
LaFever, B. J. & Imamura, F. Effects of nasal inflammation on the olfactory bulb. J. Neuroinflammation 19 (1), 294. https://doi.org/10.1186/s12974-022-02657-x (2022).
doi: 10.1186/s12974-022-02657-x
pubmed: 36494744
pmcid: 9733073
Bachert, C. et al. Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma. J. Allergy Clin. Immunol. 130 (2), 376–81e8. https://doi.org/10.1016/j.jaci.2012.05.012 (2012).
doi: 10.1016/j.jaci.2012.05.012
pubmed: 22738677
Ha, J. G. et al. Development of a Korean culture-friendly olfactory function test and optimization of a diagnostic cutoff value. Clin. Exp. Otorhinolaryngol. 13 (3), 274–284. https://doi.org/10.21053/ceo.2020.00864 (2020).
doi: 10.21053/ceo.2020.00864
pubmed: 32668827
pmcid: 7435434
Hwang, C. S. et al. Development of a gustatory function test for clinical application in Korean subjects. Yonsei Med. J. 59 (2), 325–330. https://doi.org/10.3349/ymj.2018.59.2.325 (2018).
doi: 10.3349/ymj.2018.59.2.325
pubmed: 29436203