Genetic Signatures:

Humans Hyaluronan Receptors / genetics Polymorphism, Single Nucleotide Squamous Cell Carcinoma of Head and Neck / genetics Female Male Middle Aged Head and Neck Neoplasms / genetics Genetic Predisposition to Disease Aged Case-Control Studies Genotype Adult Gene Expression Regulation, Neoplastic

Journal

JCO global oncology
ISSN: 2687-8941
Titre abrégé: JCO Glob Oncol
Pays: United States
ID NLM: 101760170

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 31 10 2024
Statut: ppublish

Résumé

This study aimed to investigate the impact of single-nucleotide polymorphisms (SNPs) in the The study involved analysis of 85 samples and 85 healthy controls. Immunohistochemistry (IHC) and flow cytometry were used to assess cell surface protein expression using CD44 antibody. DNA from formalin-fixed paraffin-embedded tissue sections was isolated and amplified using targeted primers. Sanger sequencing of the resultant amplified products was performed to determine the genotypes of the A comparison between patients with HNSCC and healthy controls revealed a significant association between The T allele and homozygous TT genotype of

Identifiants

DOI: 10.1200/GO.24.00084 PMID: 39481067
pubmed: 39481067
doi: 10.1200/GO.24.00084
doi:

Substances chimiques

Hyaluronan Receptors 0
CD44 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2400084

Auteurs

Muhammad Kashif (M)

Department of Oral Pathology, University of Health Sciences, Lahore, Pakistan.
Department of Oral Pathology, Bakhtawar Amin Medical and Dental College, Multan, Pakistan.
ORCID: 0000-0002-1427-8893

Shah Jahan (S)

Institute of Allied Health Sciences, University of Health Sciences, Lahore, Pakistan.
ORCID: 0000-0002-1730-5025

Sadia Minhas (S)

Department of Oral Pathology, Akhtar Saeed Medical and Dental College, Lahore, Pakistan.
ORCID: 0000-0001-8463-2539

Ali Amar (A)

Institute of Allied Health Sciences, University of Health Sciences, Lahore, Pakistan.
ORCID: 0000-0002-3240-0741

Romeeza Tahir (R)

Department of Immunology, University of Health Sciences, Lahore, Pakistan.
ORCID: 0000-0002-0878-7720

Haseeb Nisar (H)

Department of Life-Sciences, University of Management and Technology, Lahore, Pakistan.
Interdisciplinary Research Center in Finance and Digital Economy, King Fahad University of Petroleum and Minerals, Riyadh, Kingdom of Saudi Arabia.

Faheem Shehzad (F)

Institute of Allied Health Sciences, University of Health Sciences, Lahore, Pakistan.
ORCID: 0000-0002-2238-5912

Abdul Hanan Nagi (AH)

Chughtai Lahore Laboratory, Lahore, Pakistan.

Nadeem Afzal (N)

Department of Pathology, Akhtar Saeed Medical and Dental College, Lahore, Pakistan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Signatures:
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Récepteurs d'écotaxie des lymphocytes › Antigènes CD44 › Genetic Signatures:
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetic Signatures:
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Genetic Signatures:
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic Signatures:
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Genetic Signatures:
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic Signatures:
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic Signatures:
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Genetic Signatures:
questionsmedicales.fr › Phénomènes génétiques › Génotype › Genetic Signatures:
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic Signatures:
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Genetic Signatures: