New diagnostic techniques for diagnosing facture-related infections.

Humans Prosthesis-Related Infections / diagnosis Fractures, Bone Algorithms Metagenomics / methods
Culture Fracture-related infection Host factors Mircobiological diagnostics Sonication

Journal

Injury
ISSN: 1879-0267
Titre abrégé: Injury
Pays: Netherlands
ID NLM: 0226040

Informations de publication

Date de publication:
Nov 2024
Historique:
received: 29 02 2024
revised: 04 09 2024
accepted: 15 09 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 31 10 2024
Statut: ppublish

Résumé

The diagnosis of fracture-related infections (FRI) is challenging and requires interdisciplinary efforts. Many diagnostic approaches are based on the algorithms established for prosthetic joint infections (PJI). Data specific to FRI are limited. Microbiological diagnostics include tissue culture, sonication, and molecular methods. Novel metagenomic analyses are increasingly being used in clinical diagnostic practice. In addition to bacterial detection, the study of host tissue factors has the potential to transform the diagnostics of FRI by facilitating the assesment of clinical significance in clinical samples. The integration of host tissue analysis into microbiology reports has great potential to improve the diagnosis of FRI. This mini-review describes the potential improvement of diagnostic techniques by integrating new approaches into the diagnostic algorithm of fracture-related infections.

Identifiants

DOI: 10.1016/j.injury.2024.111898 PMID: 39482031
pubmed: 39482031
pii: S0020-1383(24)00627-2
doi: 10.1016/j.injury.2024.111898
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111898

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest Ada Hoffmann(1): AH received a travel grant from Gilead. Jörgen Hoffmann(2): No conflict of interest. Tamara Ruegamer(1): TR received lecture honoraria from Hikma. Norma Jung(3): NJ has received lecture fees from AbbVie, Bayer, Infectopharm, and Medacta and travel grants from Gilead and Pfizer and fees for advisory board from MSD. Ronald Man Yeung Wong(4): No conflict of interest. Volker Alt(5): No conflict of interest. Peer Eysel(2): No conflict of interest. Jonathan Jantsch(1,6): No conflict of interest.

Auteurs

Ada Hoffmann (A)

Institute for Medical Microbiology, Immunology, and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.

Jörgen Hoffmann (J)

Department for Orthopaedic and Trauma Surgery, Faculty of Medicine, University Hospital of Cologne, Joseph-Stelzmann Strasse 24, 50931 Cologne, Germany.

Tamara Ruegamer (T)

Institute for Medical Microbiology, Immunology, and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.

Norma Jung (N)

Department I of Internal Medicine, Infectious Diseases, Medical Faculty, University Hospital of Cologne, University of Cologne, Cologne, Germany.

Ronald Man Yeung Wong (RMY)

Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China.

Volker Alt (V)

Department of Trauma Surgery, University Hospital Regensburg, Regensburg, Germany.

Peer Eysel (P)

Department for Orthopaedic and Trauma Surgery, Faculty of Medicine, University Hospital of Cologne, Joseph-Stelzmann Strasse 24, 50931 Cologne, Germany.

Jonathan Jantsch (J)

Institute for Medical Microbiology, Immunology, and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. Electronic address: Jonathan.Jantsch@uk-koeln.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New diagnostic techniques for diagnosing...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Infections dues aux prothèses › New diagnostic techniques for diagnosing...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › New diagnostic techniques for diagnosing...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › New diagnostic techniques for diagnosing...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Métagénomique › New diagnostic techniques for diagnosing...