The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation.
Gene expression
Sex differences
X chromosome
XY* mouse model
Y chromosome
Journal
Biology of sex differences
ISSN: 2042-6410
Titre abrégé: Biol Sex Differ
Pays: England
ID NLM: 101548963
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
received:
24
07
2024
accepted:
21
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
The Four Core Genotypes (FCG) mouse model has become a valuable model to study the mechanistic basis for biological sex differences. This model allows discrimination between influences of gonadal sex (ovaries or testes) from those associated with genetic sex (presence of XX or XY chromosome complement). FCG mice have illuminated distinct effects of gonadal and chromosomal sex on traits ranging from brain structure and behavior to vulnerability to obesity, atherosclerosis, multiple sclerosis, Alzheimer's and other diseases. A recent study determined that the Y
Identifiants
pubmed: 39482704
doi: 10.1186/s13293-024-00665-5
pii: 10.1186/s13293-024-00665-5
doi:
Types de publication
Journal Article
Review
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
90Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK134148
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128898
Pays : United States
Organisme : American Heart Association
ID : 24CDA1269864
Organisme : NHLBI NIH HHS
ID : U54 HL170326
Pays : United States
Informations de copyright
© 2024. The Author(s).
Références
Gompers A, Oliver MT, Maney DL. Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses. Biol Sex Differ. 2024;15:32.
doi: 10.1186/s13293-024-00610-6
pubmed: 38570790
pmcid: 10988906
Arnold AP. Four Core Genotypes and XY* mouse models: update on impact on SABV research. Neurosci Biobehav Rev. 2020;119:1–8.
doi: 10.1016/j.neubiorev.2020.09.021
pubmed: 32980399
pmcid: 7736196
Wiese CB, Avetisyan R, Reue K. The impact of chromosomal sex on cardiometabolic health and disease. Trends Endocrinol Metab. 2023;34:652–65.
doi: 10.1016/j.tem.2023.07.003
pubmed: 37598068
pmcid: 11090013
Reue K, Wiese CB. Illuminating the mechanisms underlying sex differences in cardiovascular disease. Circ Res. 2022;130:1747–62.
doi: 10.1161/CIRCRESAHA.122.320259
pubmed: 35679362
pmcid: 9202078
Burgoyne PS, Arnold AP. A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues. Biol Sex Differ. 2016;7:68.
doi: 10.1186/s13293-016-0115-5
pubmed: 27999654
pmcid: 5154145
Panten J, Del Prete S, Cleland JP, Saunders LM, van Riet J, Schneider A, et al. Four-Core Genotypes mice harbour a 3.2 MB X–Y translocation that perturbs Tlr7 dosage. Nat Commun. 2024;15:8814.
doi: 10.1038/s41467-024-52640-8
pubmed: 39394207
pmcid: 11470063
Berletch JB, Ma W, Yang F, Shendure J, Noble WS, Disteche CM, et al. Escape from X inactivation varies in mouse tissues. PLoS Genet. 2015;11: e1005079.
doi: 10.1371/journal.pgen.1005079
pubmed: 25785854
pmcid: 4364777
Morgan AP, Gatti DM, Najarian ML, Keane TM, Galante RJ, Pack AI, et al. Structural variation shapes the landscape of recombination in mouse. Genetics. 2017;206:603–19.
doi: 10.1534/genetics.116.197988
pubmed: 28592499
pmcid: 5499175
Mauvais-Jarvis F, Arnold AP, Reue K. A Guide for the design of pre-clinical studies on sex differences in metabolism. Cell Metab. 2017;25:1216–30.
doi: 10.1016/j.cmet.2017.04.033
pubmed: 28591630
pmcid: 5516948
Davis EJ, Broestl L, Williams G, Garay BI, Lobach I, Devidze N, et al. A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease. Sci Transl Med. 2020;12:eaaz5677.
doi: 10.1126/scitranslmed.aaz5677
pubmed: 32848093
pmcid: 8409261
Link JC, Wiese CB, Chen X, Avetisyan R, Ronquillo E, Ma F, et al. X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. J Clin Invest. 2020;130:5688–702.
doi: 10.1172/JCI140223
pubmed: 32701509
pmcid: 7598065
Cheng MI, Li JH, Riggan L, Chen B, Tafti RY, Chin S, et al. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. Nat Immunol. 2023;24:780–91.
doi: 10.1038/s41590-023-01463-8
pubmed: 36928413
Cunningham CM, Li M, Ruffenach G, Doshi M, Aryan L, Hong J, et al. Y-chromosome gene, uty, protects against pulmonary hypertension by reducing proinflammatory chemokines. Am J Respir Crit Care Med. 2022;206:186–96.
doi: 10.1164/rccm.202110-2309OC
pubmed: 35504005
pmcid: 9887415
Itoh Y, Golden LC, Itoh N, Matsukawa MA, Ren E, Tse V, et al. The X-linked histone demethylase Kdm6a in CD4
doi: 10.1172/JCI126250
pubmed: 31403472
pmcid: 6715385
Zhang P, Munier JJ, Wiese CB, Vergnes L, Link JC, Abbasi F, et al. X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction. Nat Commun. 2024;15:5571.
doi: 10.1038/s41467-024-49764-2
pubmed: 38956041
pmcid: 11219728
Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, et al. Landscape of X chromosome inactivation across human tissues. Nature. 2017;550:244–8.
doi: 10.1038/nature24265
pubmed: 29022598
pmcid: 5685192
Bellott DW, Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Cho T-J, et al. Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators. Nature. 2014;508:494–9.
doi: 10.1038/nature13206
pubmed: 24759411
pmcid: 4139287
Souyris M, Mejía JE, Chaumeil J, Guéry JC. Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation. Semin Immunopathol. 2019;41:153–64.
doi: 10.1007/s00281-018-0712-y
pubmed: 30276444
Youness A, Miquel CH, Guéry JC. Escape from X chromosome inactivation and the female predominance in autoimmune diseases. Int J Mol Sci. 2021;22:1114.
doi: 10.3390/ijms22031114
pubmed: 33498655
pmcid: 7865432
Eicher EM, Hale DW, Hunt PA, Lee BK, Tucker PK, King TR, et al. The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region. Cytogenet Cell Genet. 1991;57:221–30.
doi: 10.1159/000133152
pubmed: 1743079
Schaum N, Karkanias J, Neff NF, May AP, Quake SR, Wyss-Coray T, et al. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018;562:367–72.
doi: 10.1038/s41586-018-0590-4
pmcid: 6642641
Benavides F, Rülicke T, Prins JB, Bussell J, Scavizzi F, Cinelli P, et al. Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA working group report. Lab Anim. 2020;54:135–48.
doi: 10.1177/0023677219867719
pubmed: 31431136